Figure 5

Dynamic translocation of STIM1 into neuronal filopodia in response to store-depletion. Representative time-lapse fluorescent images of growth cone expressing YFP-XSTIM1 before (1 mM Ca²⁺) and after store Ca²⁺ depletion (0 mM Ca²⁺/CPA). mCherry was co-expressed to mark filopodia and growth cone. Images were pseudocolored to enhance the observation of intensity changes. The arrows indicate newly translocated XSTIM1 proteins into neuronal filopodia. Scale bars: 10 μm.