Dynamic translocation of STIM1 into neuronal filopodia in response to store-depletion. Representative time-lapse fluorescent images of growth cone expressing YFP-XSTIM1 before (1 mM Ca2+) and after store Ca2+ depletion (0 mM Ca2+/CPA). mCherry was co-expressed to mark filopodia and growth cone. Images were pseudocolored to enhance the observation of intensity changes. The arrows indicate newly translocated XSTIM1 proteins into neuronal filopodia. Scale bars: 10 μm.