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Figure 1 | Molecular Brain

Figure 1

From: Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis

Figure 1

Vps35 expression in developing mouse retinas. (A) X-gal staining (Blue color) showed lacZ gene expression in the retina of vps35+/m mice at indicated ages. Scale bar, 200 μm. (B) The high magnification of X-gal staining images was shown. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; OS: outer segment; IS, inner segment. Scale bar, 50 μm. In addition to GCL, a few LacZ positive cells were detected in INL indicated by arrow heads. (C) Western blot analysis of VPS35 expression in retina homogenates from vps35+/+ and +/m at indicated ages. (D) Quantification analysis of percentage of LacZ positive cells. (E) Quantification analysis of VPS35 protein levels in retina from indicated age-groups of vps35+/+ and +/m mice. In (D-E), mean+/-SEM (n = 5) were presented.

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Molecular Brain

ISSN: 1756-6606