Figure 2
From: The impact of human hyperekplexia mutations on glycine receptor structure and function
pLGIC structure and the locations of hGlyR hyperekplexia mutations. The top panel shows the pentameric structure of the C. elegans α glutamate-gated chloride channel receptor (PDB 3RIF[31]) viewed from within the membrane (A) and from the presynaptic terminal (B). One subunit is coloured light grey. Panels C-F show a single pLGIC subunit with the locations of dominant and recessive mutations in the α1 and β hGlyR subunits coloured in green (missense), red (nonsense) or black (deletions). TM2 is coloured dark grey.