Figure 10

Anandamide (AEA) postpones AISS induction at hippocampal GABAergic neurons. AISS is induced under the control and subsequent use of AEA (5 μM)I after the first round of AISS disappears for 6 minutes, a time interval similar to Figure 1. A) shows AISS induction under the control (top trace) and in presence of AEA (bottom trace). Calibration bars are 20 mV and 10 seconds. B) shows the dynamical changes in threshold potentials under the control (blue symbols) and in presence of AEA (red symbols). C) illustrates the number of spikes needed for AISS onset under the control (blue bar) and in presence of AEA (red bar; asterisk, p < 0.01, n = 9).