Fig. 9
From: Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens
GluA2-lacking receptors in the NAc regulate depression-like behaviors induced by persistent inflammatory pain but not short-term postoperative pain. a Schematic showing Naspm infusion. b Placement of injectors depicted by red circles. c Timeline for experiments in PI-treated rats. d, Naspm infusion into the NAc core did not change mechanical hypersensitivity in PI-treated rats (1 day after procedure). Student’s t-test, n = 6 (Saline); n = 7 (Naspm), p > 0.05. e Naspm did not change sucrose preference in PI-treated rats. Student’s t-test, n = 8 (Saline); n = 8 (Naspm), p > 0.05. f Timeline for experiments in CFA-treated rats. g Naspm infusion into the NAc did not change mechanical hypersensitivity in CFA-treated rats (7 days after injection). Student’s t-test, n = 7 (Saline); n = 7 (Naspm), p > 0.05. h Naspm in the NAc reduced sucrose preference in CFA-treated rats. Student’s t-test, n = 9 (Saline); n = 8 (Naspm), *p < 0.05. Error bars show mean and SEM