Fig. 2
From: Targeting NMDA receptors in stroke: new hope in neuroprotection
Perturbing the GluN2B-PSD95-nNOS complex protects neurons from ischemic injury. a The activity of GluN2B-containing NMDARs is linked to the downstream nNOS and production of NO through the scaffolding protein PSD95. Over-activation of NMDARs in excitotoxicity produces a toxic level of NO and leads to neuronal death. b Interfering peptides and small molecules disrupting the protein complex can reduce NO production and prevent stroke damage