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Fig. 1 | Molecular Brain

Fig. 1

From: Naked mole-rat cortical neurons are resistant to acid-induced cell death

Fig. 1

Electrophysiological properties of NMR neurons differ from mouse neurons. NMR cortical and hippocampal neurons have significantly smaller capacitance (a) and more hyperpolarized resting membrane potential (b) than mouse neurons. c Example of whole-cell patch-clamp recordings made from a mouse (left, black) and a NMR (middle, blue) hippocampal neuron in response to the voltage step protocol and the inhibition of response in NMR neurons by 300 nM TTX (right, blue). Cortical and hippocampal NMR neurons have significantly smaller voltage-gated inward currents (a, b), a more depolarized Vhalf (c) and a more depolarized peak activation membrane potential Vm (d) compared to mouse neurons. e. Voltage-gated outward currents in NMR cortical and hippocampal show no significant difference to those in mouse neurons. * p < 0.5; ** p < 0.01; **** p < 0.0001, unpaired t-tests within each structure. Numbers in brackets indicate the number of recorded cells

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