Fig. 4

Cognitive function of Trpm1^−/− mice. Fear conditioning test; a distance traveled in the conditioning phase, b percentage of freezing time in the conditioning phase. Conditioned stimulus (CS: white noise) and unconditioned stimulus (US: foot shock) were presented, c distance traveled during and after foot shocks, d percentage of freezing time in the context tests or cued tests at 1 day and 30 days after conditioning, e distance traveled in the context tests or cued tests at 1 day and 30 days after conditioning. n = 24 for both genotypes. Barnes maze test; f distance, g error count, h latency to first reach the correct hole above the escape box in the training, acquisition and reversal sessions, Time spent around each hole in the probe trial conducted 24 h (i), 1 month (j) after the last training session and 24 h after last reversal training session (k). n = 24 for both genotypes. T-maze forced alternation task test; l percentage of correct responses, m latency, n distance traveled. n = 24 for both genotypes. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; repeated measures 2-way ANOVA (a–h, l–n), Student’s t test (i, k), Welch’s t test (j)