Fig. 1
From: Central and peripheral contributions of T-type calcium channels in pain
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13041-022-00923-w/MediaObjects/13041_2022_923_Fig1_HTML.png)
Electrophysiological properties of T-type channels. a Typical inward current recorded from T-type channels during an IV-curve. Note that inward current in response to depolarization is rapidly activating and rapidly inactivating. b Typical steady state activation and inactivation curves for T-type channels. Current activation occurs near − 60 mV and reaches peak around − 20 mV. Overlap of activation and inactivation curves reveals a significant window current between -60 and -40 mV. c Adapted with permission from Joksimovic et al. [33]. Perfusion of 10 µM TTA-P2 significantly reduces burst firing in response to current injection (top) and rebound bursting (bottom) in subicular neurons, revealing the contribution of T-type channels to activity in these neurons