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Fig. 5 | Molecular Brain

Fig. 5

From: Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

Fig. 5

Reduced levels of TJs due to BBB dysfunction lead to pericyte degeneration causing infiltration of antibodies (IgG), intercellular adhesion molecule (ICAM-1/2/vascular cell adhesion molecules (VCAM), thrombin, plasminogen, haemoglobin (Hb) and iron (II) released from RBCs further produce ROS in the matrix, toxic for motor neurons in case of ALS. This figure is adapted from [66]

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Molecular Brain

ISSN: 1756-6606