Fig. 3
From: Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Working memory is impaired in 4EHP-CaMKIIα KO mice. A Schematic depicting contextual fear conditioning (CFC) training and short-term memory test regime. B Short-term contextual fear memory calculated by % freezing 1 h after receiving a mild foot shock (0.3 mA, 1 s) (WT n = 10, cKOexc n = 9). C Schematic depicting T-maze spatial WM test. Mice were placed in a T-maze facing away from the junction (starting point) with one of either arm blocked for 10 min. After 1 h, mice were placed back in the maze with free access to both arms for 10 min of exploration. D T-maze memory is shown as a discrimination index for the novel vs. familiar arm where 0% means equal time spent in both arms (WT n = 11, cKOexc n = 12). E Total exploration in either arm. Data are presented as mean ± s.e.m. ###p < 0.001; ns, not significant. P value calculated using one sample t-test or unpaired t-test. Sample size is located within the bar graph for each group