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  2. Results of recent genome-wide association studies (GWAS) and whole genome sequencing (WGS) highlighted type II cadherins as risk genes for autism spectrum disorders (ASD). To determine whether these cadherins ...

    Authors: Chunlei Wang, Yi-Hsuan Pan, Yue Wang, Gene Blatt and Xiao-Bing Yuan
    Citation: Molecular Brain 2019 12:40
    Content type: Research Published on:

  3. TMP21, a type I transmembrane protein of thep24 protein family, mediates protein trafficking and maturation. Dysregulation of TMP21 is implicated in the pathogenesis of Alzheimer’s disease (AD). However, under...

    Authors: Xiaojie Zhang, Yili Wu, Fang Cai and Weihong Song
    Citation: Molecular Brain 2019 12:39
    Content type: Research Published on:

  4. Itch contagion has been reported in human when people watch someone scratching in a video. The basic mechanism of contagious itch induced by scratching video is still being investigated. A recent study has rep...

    Authors: Jing-Shan Lu, Qi-Yu Chen, Si-Bo Zhou, Feng-Yi Wu, Ren-Hao Liu, Zhao-Xiang Zhou, Hua Zhang and Min Zhuo
    Citation: Molecular Brain 2019 12:38
    Content type: Research Published on:

  5. Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved e...

    Authors: Jisoo Lim, Eosu Kim, Hyun Jong Noh, Shinwon Kang, Benjamin U. Phillips, Dong Goo Kim, Timothy J. Bussey, Lisa Saksida, Christopher J. Heath and Chul Hoon Kim
    Citation: Molecular Brain 2019 12:37
    Content type: Research Published on:

  6. Chronic pain is commonly accompanied with anxiety disorder, which complicates treatment. In this study, we investigated the analgesic and anxiolytic effects of Formononetin (FMNT), an active component of tradi...

    Authors: Xin-shang Wang, Shao-yu Guan, An Liu, Jiao Yue, Li-ning Hu, Kun Zhang, Liu-kun Yang, Liang Lu, Zhen Tian, Ming-gao Zhao and Shui-bing Liu
    Citation: Molecular Brain 2019 12:36
    Content type: Research Published on:

  7. Huntington’s disease (HD) is a neurodegenerative disorder caused by a genetic abnormality in the huntingtin gene that leads to a polyglutamine repeat expansion of the huntingtin protein. The cleaved polyglutam...

    Authors: Khaled S. Abd-Elrahman and Stephen S. G. Ferguson
    Citation: Molecular Brain 2019 12:35
    Content type: Short report Published on:

  8. The physiological functions controlled by T-type channels are intrinsically dependent on their gating properties, and alteration of T-type channel activity is linked to several human disorders. Therefore, it i...

    Authors: Bohumila Jurkovicova-Tarabova, Leos Cmarko, Renata Rehak, Gerald W. Zamponi, Lubica Lacinova and Norbert Weiss
    Citation: Molecular Brain 2019 12:34
    Content type: Research Published on:

  9. Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several au...

    Authors: Pureum Jeon, Ju-Hui Park, Yong-Woo Jun, You-Kyung Lee, Deok-Jin Jang and Jin-A Lee
    Citation: Molecular Brain 2019 12:33
    Content type: Micro report Published on:

  10. Calcium/Calmodulin-dependent protein kinase II (CaMKII) plays a key role in the molecular mechanism of memory formation. CaMKII is known to be activated specifically in the activated spines during memory forma...

    Authors: Sanghyun Ye, Ji-il Kim, Jooyoung Kim and Bong-Kiun Kaang
    Citation: Molecular Brain 2019 12:32
    Content type: Micro report Published on:

  11. Merkel discs, located in skin touch domes and whisker hair follicles, are tactile end organs essential for environmental exploration, social interaction, and tactile discrimination. Recent studies from our gro...

    Authors: Mayumi Sonekatsu, Steven Lawrence Gu, Hirosato Kanda and Jianguo G. Gu
    Citation: Molecular Brain 2019 12:31
    Content type: Micro report Published on:

  12. Theta-burst stimulation (TBS) induces short-term potentiation (STP) plus two types of transcriptionally-independent forms of long-term potentiation (LTP), termed LTP1 and LTP2. We have compared the susceptibil...

    Authors: Pojeong Park, Thomas M. Sanderson, Zuner A. Bortolotto, John Georgiou, Min Zhuo, Bong-Kiun Kaang and Graham L. Collingridge
    Citation: Molecular Brain 2019 12:30
    Content type: Micro report Published on:

  13. Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressant drugs in pregnant women. Infants born following prenatal exposure to SSRIs have a higher risk for behavioral abnormalities...

    Authors: Weonjin Yu, Yi-Chun Yen, Young-Hwan Lee, Shawn Tan, Yixin Xiao, Hidayat Lokman, Audrey Khoo Tze Ting, Hasini Ganegala, Taejoon Kwon, Won-Kyung Ho and H. Shawn Je
    Citation: Molecular Brain 2019 12:29
    Content type: Research Published on:

  15. The amyloid precursor protein (APP) is endoproteolytically processed to generate either the neurotoxic beta-amyloid peptide (Aβ) or the secreted ectodomain APP alpha (sAPPα). While neurotrophic properties of s...

    Authors: Christian Tackenberg and Roger M. Nitsch
    Citation: Molecular Brain 2019 12:27
    Content type: Micro report Published on:

  16. A major barrier to the effective conduct of clinical trials of new drug candidates against Alzheimer’s disease (AD) and to identifying patients for receiving future disease-modifying treatments is the limited ...

    Authors: Henrik Zetterberg and Samantha C. Burnham
    Citation: Molecular Brain 2019 12:26
    Content type: Review Published on:

  17. Posttraumatic stress disorder is developed by exposure to a threatening and/or a horrifying event and characterized by the presence of anxiety, hyperarousal, avoidance, and sleep abnormality for a prolonged pe...

    Authors: Mikiei Tanaka, Hongyun Li, Xijun Zhang, Jatinder Singh, Clifton L. Dalgard, Matthew Wilkerson and Yumin Zhang
    Citation: Molecular Brain 2019 12:25
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Brain 2019 12:47

  19. It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintai...

    Authors: Chang Shan, Arijit Ghosh, Xing-zhi Guo, Shu-min Wang, Yan-fang Hou, Sheng-tian Li and Jian-min Liu
    Citation: Molecular Brain 2019 12:23
    Content type: Review Published on:

  21. Information from direct experience and observation of others is integrated in the brain to enable appropriate responses to environmental stimuli. Fear memory can be acquired by observing a conspecific’s distre...

    Authors: Hiroshi Nomura, Chie Teshirogi, Daisuke Nakayama, Masabumi Minami and Yuji Ikegaya
    Citation: Molecular Brain 2019 12:21
    Content type: Research Published on:

  22. Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synap...

    Authors: Michinori Koebis, Shinji Urata, Yo Shinoda, Shigeo Okabe, Tatsuya Yamasoba, Kazuki Nakao, Atsu Aiba and Teiichi Furuichi
    Citation: Molecular Brain 2019 12:20
    Content type: Research Published on:

  23. Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS [MIM 270550]) is an early-onset neurodegenerative disorder caused by mutations in the SACS gene. Over 200 SACS mutations have been identified. Mos...

    Authors: Roxanne Larivière, Nicolas Sgarioto, Brenda Toscano Márquez, Rébecca Gaudet, Karine Choquet, R. Anne McKinney, Alanna J. Watt and Bernard Brais
    Citation: Molecular Brain 2019 12:19
    Content type: Research Published on:

  24. A number of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, share intra- and/or extracellular deposition of protein aggregates as a common cor...

    Authors: Jae-Young Koh, Ha Na Kim, Jung Jin Hwang, Yang-Hee Kim and Sang Eun Park
    Citation: Molecular Brain 2019 12:18
    Content type: Review Published on:

  25. Hypomyelination in the central nerves system (CNS) is one of the most obviously pathological features in Niemann-Pick Type C disease (NPC), which is a rare neurodegenerative disorder caused by mutations in the...

    Authors: Fan Yang, Yudong Guan, Xiao Feng, Arndt Rolfs, Hartmut Schlüter and Jiankai Luo
    Citation: Molecular Brain 2019 12:17
    Content type: Research Published on:

  26. Parkinson’s disease (PD) and Alzheimer’s disease (AD) are the most common neurodegenerative diseases and have been suggested to share common pathological and physiological links. Understanding the cross-talk b...

    Authors: Jack Kelly, Rana Moyeed, Camille Carroll, Diego Albani and Xinzhong Li
    Citation: Molecular Brain 2019 12:16
    Content type: Research Published on:

  27. Spinophilin is a scaffolding protein enriched in dendritic spines with integral roles in the regulation of spine density and morphology, and the modulation of synaptic plasticity. The ability of spinophilin to...

    Authors: Lorena Bianchine Areal, Alison Hamilton, Cristina Martins-Silva, Rita Gomes Wanderley Pires and Stephen S. G. Ferguson
    Citation: Molecular Brain 2019 12:15
    Content type: Research Published on:

  28. Studies have shown that a normal circadian rhythm is crucial to learning and memory. Circadian rhythm disturbances that occur at early stages of Alzheimer’s disease (AD) aggravate the progression of the diseas...

    Authors: Li Wang, Rui Zhang, Xiaohong Hou, Changtu Wang, Shuai Guo, Na Ning, Cong Sun, Yuan Yuan, Lin Li, Christian Hölscher and Xiaohui Wang
    Citation: Molecular Brain 2019 12:14
    Content type: Research Published on:

  29. The cerebellum regulates complex animal behaviors, such as motor control and spatial recognition, through communication with many other brain regions. The major targets of the cerebellar projections are the th...

    Authors: Nobuyuki Sakayori, Shigeki Kato, Masateru Sugawara, Susumu Setogawa, Hotaka Fukushima, Rie Ishikawa, Satoshi Kida and Kazuto Kobayashi
    Citation: Molecular Brain 2019 12:13
    Content type: Research Published on:

  30. This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels i...

    Authors: Agustin Garcia-Caballero, Maria A. Gandini, Shuo Huang, Lina Chen, Ivana A. Souza, Yan L. Dang, M. Jackson Stutts and Gerald W. Zamponi
    Citation: Molecular Brain 2019 12:12
    Content type: Research Published on:

  32. Chronic opiate exposure induces neuroadaptations in the mesocorticolimbic system including ventral tegmental area (VTA) dopamine (DA) neurons, whose soma size is decreased following opiate exposure. Yet it is ...

    Authors: Sarah C. Simmons, Katie Wheeler and Michelle S. Mazei-Robison
    Citation: Molecular Brain 2019 12:10
    Content type: Research Published on:

  33. Correction to: Molecular Brain (2018) 11:52 https://doi.org/10.1186/s13041-018-0394-3

    Authors: Bong Soo Seok, Feng Cao, Erika Bélanger-Nelson, Chloé Provost, Steve Gibbs, Zhengping Jia and Valérie Mongrain
    Citation: Molecular Brain 2019 12:9
    Content type: Correction Published on:

    The original article was published in Molecular Brain 2018 11:52

  37. Parkinson’s disease (PD) is associated with both motor and non-motor symptoms, including constipation, sensory neuropathy, depression, dementia and sleep disorder. Somatostatin (SST) is considered to be a modu...

    Authors: Chizuru Iwasawa, Naoko Kuzumaki, Yukari Suda, Reiko Kagawa, Yuko Oka, Nobutaka Hattori, Hideyuki Okano and Minoru Narita
    Citation: Molecular Brain 2019 12:5
    Content type: Short report Published on:

  38. Traumatic spinal cord injury (SCI) causes serious disruption of neuronal circuits that leads to motor functional deficits. Regeneration of disrupted circuits back to their original target is necessary for the ...

    Authors: Kazuya Yokota, Kensuke Kubota, Kazu Kobayakawa, Takeyuki Saito, Masamitsu Hara, Ken Kijima, Takeshi Maeda, Hiroyuki Katoh, Yasuyuki Ohkawa, Yasuharu Nakashima and Seiji Okada
    Citation: Molecular Brain 2019 12:4
    Content type: Research Published on:

  39. The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic au...

    Authors: Hiroko Kotajima-Murakami, Toshiyuki Kobayashi, Hirofumi Kashii, Atsushi Sato, Yoko Hagino, Miho Tanaka, Yasumasa Nishito, Yukio Takamatsu, Shigeo Uchino and Kazutaka Ikeda
    Citation: Molecular Brain 2019 12:3
    Content type: Research Published on:

  40. Previous gain-of-function studies using an optogenetic technique showed that manipulation of the hippocampal dentate gyrus or CA1 cell ensembles is important for memory reactivation and to generate synthetic o...

    Authors: Naoya Oishi, Masanori Nomoto, Noriaki Ohkawa, Yoshito Saitoh, Yoshitake Sano, Shuhei Tsujimura, Hirofumi Nishizono, Mina Matsuo, Shin-ichi Muramatsu and Kaoru Inokuchi
    Citation: Molecular Brain 2019 12:2
    Content type: Research Published on:

  41. Natural aggressiveness is commonly observed in all animal species, and is displayed frequently when animals compete for food, territory and mating. Aggression is an innate behaviour, and is influenced by both ...

    Authors: Mahmoudreza Ramin, Yueyang Li, Wen-Tzu Chang, Hunter Shaw and Yong Rao
    Citation: Molecular Brain 2019 12:1
    Content type: Research Published on:

  43. Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on ‘Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)’. John had no opportunity to rea...

    Authors: Mark F. Bear, Sam F. Cooke, Karl Peter Giese, Bong-Kiun Kaang, Mary B. Kennedy, Ji-il Kim, Richard G. M. Morris and Pojeong Park
    Citation: Molecular Brain 2018 11:76
    Content type: Commentary Published on:

  44. Accumulating evidence indicates that microglia activation is associated with an increased risk for developing Parkinson’s disease (PD). With the progressive and selective degeneration of dopaminergic (DA) neur...

    Authors: Fangfang Dou, Xinkun Chu, Bei Zhang, Liang Liang, Guoqiang Lu, Jianqing Ding and Shengdi Chen
    Citation: Molecular Brain 2018 11:75
    Content type: Research Published on:

  45. Higher dietary intakes of saturated fatty acid increase the risk of developing Alzheimer’s disease and dementia, and even in people without diabetes higher glucose levels may be a risk factor for dementia. The...

    Authors: Young-Suk Choi, Somang Kang, Sang-Yoon Ko, Saeram Lee, Jae Young Kim, Hansol Lee, Jae Eun Song, Dong-Hyun Kim, Eosu Kim, Chul Hoon Kim, Lisa Saksida, Ho-Taek Song and Jong Eun Lee
    Citation: Molecular Brain 2018 11:74
    Content type: Research Published on:

  48. Various mutations in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene are associated with neurodevelopmental and neuropsychiatric disorders. Thus far, synaptic abnormalities in multiple brain regions, ...

    Authors: Chunmei Jin, Hyojin Kang, Shinhyun Kim, Yinhua Zhang, Yeunkum Lee, Yoonhee Kim and Kihoon Han
    Citation: Molecular Brain 2018 11:71
    Content type: Micro report Published on:

  49. Recent development of FRET-PAINT microscopy significantly improved the imaging speed of DNA-PAINT, the previously reported super-resolution fluorescence microscopy with no photobleaching problem. Here we try t...

    Authors: Jongjin Lee, Sangjun Park and Sungchul Hohng
    Citation: Molecular Brain 2018 11:70
    Content type: Research Published on:

  50. Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma. Retinal ganglion cell neurite...

    Authors: James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel and James E. Morgan
    Citation: Molecular Brain 2018 11:69
    Content type: Micro report Published on:
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