Harris L, L’Italien G, O’Connell T, Hasan Z, Hutchinson S, Lucas S. A framework for estimating the eligible patient population for new migraine acute therapies in the United States. Adv Ther. 2021;38(10):5087–97.
Article
PubMed
PubMed Central
Google Scholar
Edvinsson L, Haanes KA, Warfvinge K, Krause DN. CGRP as the target of new migraine therapies—successful translation from bench to clinic. Nat Rev Neurol. 2018;14(6):338–50.
Article
CAS
PubMed
Google Scholar
Global regional. and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211–59.
Article
Google Scholar
Liu T, Gao YJ, Ji RR. Emerging role of toll-like receptors in the control of pain and itch. Neurosci Bull. 2012;28(2):131–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pereira EA, Aziz TZ. Neuropathic pain and deep brain stimulation. Neurotherapeutics. 2014;11(3):496–507.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice ASC, et al. A new definition of neuropathic pain. Pain. 2011;152(10):2204–5.
Article
PubMed
Google Scholar
Torrance N, Smith BH, Bennett MI, Lee AJ. The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey. J Pain. 2006;7(4):281–9.
Article
PubMed
Google Scholar
Bouhassira D, Lantéri-Minet M, Attal N, Laurent B, Touboul C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain. 2008;136(3):380–7.
Article
PubMed
Google Scholar
Yang H, Wu L, Deng H, Chen Y, Zhou H, Liu M, et al. Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia. J Neuroinflamm. 2020;17(1):154.
Article
CAS
Google Scholar
Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, et al. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest. 2012;122(6):2195–207.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen W, Lu Z. Upregulated TLR3 promotes neuropathic pain by regulating autophagy in rat with L5 spinal nerve ligation model. Neurochem Res. 2017;42(2):634–43.
Article
CAS
PubMed
Google Scholar
Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. J Neuroinflamm. 2013;10:148.
Article
CAS
Google Scholar
Li Y, Yin C, Li X, Liu B, Wang J, Zheng X, et al. Electroacupuncture alleviates paclitaxel-induced peripheral neuropathic pain in rats via suppressing TLR4 signaling and TRPV1 upregulation in sensory neurons. Int J Mol Sci. 2019;20(23):5917.
Article
CAS
PubMed Central
Google Scholar
Xu ZZ, Kim YH, Bang S, Zhang Y, Berta T, Wang F, et al. Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nat Med. 2015;21(11):1326–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
He L, Han G, Wu S, Du S, Zhang Y, Liu W, et al. Toll-like receptor 7 contributes to neuropathic pain by activating NF-κB in primary sensory neurons. Brain Behav Immun. 2020;87:840–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang ZJ, Guo JS, Li SS, Wu XB, Cao DL, Jiang BC, et al. TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG. J Exp Med. 2018;215(12):3019–37.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luo X, Huh Y, Bang S, He Q, Zhang L, Matsuda M, et al. Macrophage toll-like receptor 9 contributes to chemotherapy-induced neuropathic pain in male mice. J Neurosci. 2019;39(35):6848–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lacagnina MJ, Watkins LR, Grace PM. Toll-like receptors and their role in persistent pain. Pharmacol Ther. 2018;184:145–58.
Article
CAS
PubMed
Google Scholar
Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity. 2011;34(5):637–50.
Article
CAS
PubMed
Google Scholar
Anderson KV, Bokla L, Nüsslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell. 1985;42(3):791–8.
Article
CAS
PubMed
Google Scholar
Gay NJ, Keith FJ. Drosophila Toll and IL-1 receptor. Nature. 1991;351(6325):355–6.
Article
CAS
PubMed
Google Scholar
Rosetto M, Engström Y, Baldari CT, Telford JL, Hultmark D. Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line. Biochem Biophys Res Commun. 1995;209(1):111–6.
Article
CAS
PubMed
Google Scholar
Medzhitov R, Preston-Hurlburt P, Janeway CA.Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 1997;388(6640):394–7.
Article
CAS
PubMed
Google Scholar
O’Neill LA, Golenbock D, Bowie AG. The history of Toll-like receptors—redefining innate immunity. Nat Rev Immunol. 2013;13(6):453–60.
Article
PubMed
CAS
Google Scholar
Fore F, Indriputri C, Mamutse J, Nugraha J. TLR10 and its unique anti-inflammatory properties and potential use as a target in therapeutics. Immune Netw. 2020;20(3):e21.
Article
PubMed
PubMed Central
Google Scholar
Lim KH, Staudt LM. Toll-like receptor signaling. Cold Spring Harb Perspect Biol. 2013;5(1):a011247.
Article
PubMed
PubMed Central
CAS
Google Scholar
Blasius AL, Beutler B. Intracellular toll-like receptors. Immunity. 2010;32(3):305–15.
Article
CAS
PubMed
Google Scholar
McGettrick AF, O’Neill LA. Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol. 2010;22(1):20–7.
Article
CAS
PubMed
Google Scholar
Okun E, Griffioen KJ, Son TG, Lee JH, Roberts NJ, Mughal MR, et al. TLR2 activation inhibits embryonic neural progenitor cell proliferation. J Neurochem. 2010;114(2):462–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lathia JD, Okun E, Tang SC, Griffioen K, Cheng A, Mughal MR, et al. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci. 2008;28(51):13978–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rolls A, Shechter R, London A, Ziv Y, Ronen A, Levy R, et al. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Biol. 2007;9(9):1081–8.
Article
CAS
PubMed
Google Scholar
Sloane JA, Batt C, Ma Y, Harris ZM, Trapp B, Vartanian T. Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci U S A. 2010;107(25):11555–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu JW, Li YF, Wang ZT, Jia WQ, Xu RX. Toll-like receptor 4 deficiency impairs motor coordination. Front Neurosci. 2016;10:33.
PubMed
PubMed Central
Google Scholar
Anthoney N, Foldi I, Hidalgo A. Toll and Toll-like receptor signalling in development. Development. 2018;145(9):dev156018.
Article
PubMed
CAS
Google Scholar
Takeda K, Akira S. TLR signaling pathways. Semin Immunol. 2004;16(1):3–9.
Article
CAS
PubMed
Google Scholar
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11(5):373–84.
Article
CAS
PubMed
Google Scholar
Morrison DK. MAP kinase pathways. Cold Spring Harb Perspect Biol. 2012;4(11):a011254.
Article
PubMed
PubMed Central
CAS
Google Scholar
Jiang S, Li X, Hess NJ, Guan Y, Tapping RI. TLR10 is a negative regulator of both MyD88-dependent and -independent TLR signaling. J Immunol. 2016;196(9):3834–41.
Article
CAS
PubMed
Google Scholar
Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001;410(6832):1099–103.
Article
CAS
PubMed
Google Scholar
Chen WJ, Niu JQ, Chen YT, Deng WJ, Xu YY, Liu J, et al. Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice. J Headache Pain. 2021;22(1):38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Samir P, Place DE, Malireddi RKS, Kanneganti TD. TLR and IKK complex-mediated innate immune signaling inhibits stress granule assembly. J Immunol. 2021;207(1):115–24.
Article
CAS
PubMed
Google Scholar
Foster SL, Hargreaves DC, Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007;447(7147):972–8.
Article
CAS
PubMed
Google Scholar
Brenner C, Galluzzi L, Kepp O, Kroemer G. Decoding cell death signals in liver inflammation. J Hepatol. 2013;59(3):583–94.
Article
CAS
PubMed
Google Scholar
Perry CJ, Blake P, Buettner C, Papavassiliou E, Schain AJ, Bhasin MK, et al. Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: implications for extracranial origin of headache. Ann Neurol. 2016;79(6):1000–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Takizawa T, Shibata M, Kayama Y, Shimizu T, Toriumi H, Ebine T, et al. High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression. J Cereb Blood Flow Metab. 2017;37(3):890–901.
Article
CAS
PubMed
Google Scholar
Ghaemi A, Sajadian A, Khodaie B, Lotfinia AA, Lotfinia M, Aghabarari A, et al. Immunomodulatory effect of toll-like receptor-3 ligand poly I:C on cortical spreading depression. Mol Neurobiol. 2016;53(1):143–54.
Article
CAS
PubMed
Google Scholar
Fila M, Chojnacki J, Pawlowska E, Szczepanska J, Chojnacki C, Blasiak J. Kynurenine pathway of tryptophan metabolism in migraine and functional gastrointestinal disorders. Int J Mol Sci. 2021;22(18):10134.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ramachandran R, Wang Z, Saavedra C, DiNardo A, Corr M, Powell SB, et al. Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway. Mol Pain. 2019;15:1744806919867842.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kursun O, Yemisci M, van den Maagdenberg A, Karatas H. Migraine and neuroinflammation: the inflammasome perspective. J Headache Pain. 2021;22(1):55.
Article
PubMed
PubMed Central
Google Scholar
Karatas H, Erdener SE, Gursoy-Ozdemir Y, Lule S, Eren-Koçak E, Sen ZD, et al. Spreading depression triggers headache by activating neuronal Panx1 channels. Science. 2013;339(6123):1092–5.
Article
CAS
PubMed
Google Scholar
Conti P, D’Ovidio C, Conti C, Gallenga CE, Lauritano D, Caraffa A, et al. Progression in migraine: role of mast cells and pro-inflammatory and anti-inflammatory cytokines. Eur J Pharmacol. 2019;844:87–94.
Article
CAS
PubMed
Google Scholar
Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H. Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol. 2001;167(4):2250–6.
Article
CAS
PubMed
Google Scholar
Cseh A, Farkas KM, Derzbach L, Muller K, Vasarhelyi B, Szalay B, et al. Lymphocyte subsets in pediatric migraine. Neurol Sci. 2013;34(7):1151–5.
Article
PubMed
Google Scholar
Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 1999;285(5428):736–9.
Article
CAS
PubMed
Google Scholar
Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130(6):1071–82.
Article
CAS
PubMed
Google Scholar
Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, et al. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity. 2009;31(6):873–84.
Article
CAS
PubMed
Google Scholar
Lee CC, Avalos AM, Ploegh HL. Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol. 2012;12(3):168–79.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005;11(11):1173–9.
Article
CAS
PubMed
Google Scholar
Lim H, Lee J, You B, Oh JH, Mok HJ, Kim YS, et al. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain. EMBO J. 2020;39(6):e102214.
Article
CAS
PubMed
PubMed Central
Google Scholar
Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem. 2004;279(9):7370–7.
Article
CAS
PubMed
Google Scholar
Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest. 2005;115(8):2223–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Häcker H, et al. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem. 2001;276(33):31332–9.
Article
CAS
PubMed
Google Scholar
Barua RS, Sharma M, Dileepan KN. Cigarette smoke amplifies inflammatory response and atherosclerosis progression through activation of the H1R-TLR2/4-COX2 axis. Front Immunol. 2015;6:572.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol. 2002;61(11):1013–21.
Article
CAS
PubMed
Google Scholar
Fan J, Frey RS, Malik AB. TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest. 2003;112(8):1234–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Olson JK, Miller SD. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol. 2004;173(6):3916–24.
Article
CAS
PubMed
Google Scholar
Shi XQ, Zekki H, Zhang J. The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response. Glia. 2011;59(2):231–41.
Article
PubMed
Google Scholar
Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O’Keeffe S, et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci. 2014;34(36):11929–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Naert G, Laflamme N, Rivest S. Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain. J Innate Immun. 2009;1(5):480–93.
Article
CAS
PubMed
Google Scholar
Marshall JS, McCurdy JD, Olynych T. Toll-like receptor-mediated activation of mast cells: implications for allergic disease? Int Arch Allergy Immunol. 2003;132(2):87–97.
Article
CAS
PubMed
Google Scholar
Kilinc E, Dagistan Y, Kotan B, Cetinkaya A. Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats. Physiol Int. 2017;104(1):15–24.
Article
CAS
PubMed
Google Scholar
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732–8.
Article
CAS
PubMed
Google Scholar
Qi J, Buzas K, Fan H, Cohen JI, Wang K, Mont E, et al. Painful pathways induced by TLR stimulation of dorsal root ganglion neurons. J Immunol. 2011;186(11):6417–26.
Article
CAS
PubMed
Google Scholar
Mei XP, Zhou Y, Wang W, Tang J, Wang W, Zhang H, et al. Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain. Neurosignals. 2011;19(1):44–53.
Article
CAS
PubMed
Google Scholar
Arthur JS, Ley SC. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 2013;13(9):679–92.
Article
CAS
PubMed
Google Scholar
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell. 1998;2(2):253–8.
Article
CAS
PubMed
Google Scholar
Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature. 2005;434(7030):243–9.
Article
CAS
PubMed
Google Scholar
Strain SM, Fesik SW, Armitage IM. Characterization of lipopolysaccharide from a heptoseless mutant of Escherichia coli by carbon 13 nuclear magnetic resonance. J Biol Chem. 1983;258(5):2906–10.
Article
CAS
PubMed
Google Scholar
Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. J Neurochem. 2010;114(1):13–27.
CAS
PubMed
PubMed Central
Google Scholar
Heiman A, Pallottie A, Heary RF, Elkabes S. Toll-like receptors in central nervous system injury and disease: a focus on the spinal cord. Brain Behav Immun. 2014;42:232–45.
Article
CAS
PubMed
Google Scholar
Nicotra L, Loram LC, Watkins LR, Hutchinson MR. Toll-like receptors in chronic pain. Exp Neurol. 2012;234(2):316–29.
Article
CAS
PubMed
Google Scholar
Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, et al. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci. 2008;28(1):20–9.
Article
PubMed
PubMed Central
Google Scholar
Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, et al. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 2011;152(12):2881–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Boivin A, Pineau I, Barrette B, Filali M, Vallières N, Rivest S, et al. Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci. 2007;27(46):12565–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Church JS, Milich LM, Lerch JK, Popovich PG, McTigue DM. E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord. Glia. 2017;65(6):883–99.
Article
PubMed
PubMed Central
Google Scholar
Rafiei A, Abedini M, Hosseini SH, Hosseini-Khah Z, Bazrafshan B, Tehrani M. Toll like receptor-4 896A/G gene variation, a risk factor for migraine headaches. Iran J Immunol. 2012;9(3):159–67.
CAS
PubMed
Google Scholar
Su M, Ran Y, He Z, Zhang M, Hu G, Tang W, et al. Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine. Mol Pain. 2018;14:1744806918754612.
CAS
PubMed
PubMed Central
Google Scholar
Gong Q, Lin Y, Lu Z, Xiao Z. Microglia-astrocyte cross talk through IL-18/IL-18R signaling modulates migraine-like behavior in experimental models of migraine. Neuroscience. 2020;451:207–15.
Article
CAS
PubMed
Google Scholar
Wieseler J, Ellis A, McFadden A, Stone K, Brown K, Cady S, et al. Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators. Brain Res. 2017;1664:87–94.
Article
CAS
PubMed
PubMed Central
Google Scholar