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  1. Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root gang...

    Authors: Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang and Christophe Altier

    Citation: Molecular Brain 2020 13:61

    Content type: Research

    Published on:

  2. Sentrin/SUMO-specific protease 2 (SENP2) is a member of SENPs family involved in maturation of SUMO precursors and deSUMOylation of specific target, and is highly expressed in the central nervous system (CNS)....

    Authors: Dehua Huang, Huiqing Liu, Aoxue Zhu, Yi Zhou and Yong Li

    Citation: Molecular Brain 2020 13:59

    Content type: Research

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  3. Calcium dysregulation is a key pathological event in Alzheimer’s disease (AD). In studying approaches to mitigate this calcium overload, we identified the collapsin response mediator protein 2 (CRMP2), an axon...

    Authors: Baochang Qi, Yu Yang, Yingying Cheng, Di Sun, Xu Wang, Rajesh Khanna and Weina Ju

    Citation: Molecular Brain 2020 13:58

    Content type: Research

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  4. The neuroinflammation in the ischemic brain could occur as sterile inflammation in response to damage-associated molecular patterns (DAMPs). However, its long-term dynamic transcriptional changes remain poorly...

    Authors: Atsushi Yamaguchi, Tatsuya Jitsuishi, Takashi Hozumi, Jun Iwanami, Keiko Kitajo, Hiroo Yamaguchi, Yasutake Mori, Masaki Mogi and Setsu Sawai

    Citation: Molecular Brain 2020 13:57

    Content type: Research

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  5. The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development and are expressed by neurons in the mature brain. Netrin-1 recruits GluA1-containing α...

    Authors: Stephen D. Glasgow, Edwin W. Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S. Ruthazer and Timothy E. Kennedy

    Citation: Molecular Brain 2020 13:56

    Content type: Research

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  7. Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that are highly heterogeneous in clinical symptoms as well as etiologies. Mutations in SHANK2 are associated with ASD and accordingly, Sha...

    Authors: Yong-Seok Lee, Nam-Kyung Yu, Jeewan Chun, Jung-eun Yang, Chae-Seok Lim, Hyopil Kim, Gaeun Park, Jin-A Lee, Kyungmin Lee, Bong-Kiun Kaang and Jae-Hyung Lee

    Citation: Molecular Brain 2020 13:54

    Content type: Short report

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  9. Pathogenic variants in the gene encoding the small GTPase Ras analogue in Brain 39b (RAB39B) are associated with early-onset parkinsonism. In this study we investigated the expression and localization of RAB39...

    Authors: Yujing Gao, Gabrielle R. Wilson, Sarah E. M. Stephenson, Mustapha Oulad-Abdelghani, Nicolas Charlet-Berguerand, Kiymet Bozaoglu, Catriona A. McLean, Paul Q. Thomas, David I. Finkelstein and Paul J. Lockhart

    Citation: Molecular Brain 2020 13:52

    Content type: Short report

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  10. Hypoxic-ischemic brain damage (HIBD) is a relatively common malignant complication that occurs in newborn infants, but promising therapies remain limited. In this study, we focused on the role of miR-326 and i...

    Authors: Xuan Wang, Han Zhou, Rui Cheng, Xiaoguang Zhou, Xuewen Hou, Jun Chen and Jie Qiu

    Citation: Molecular Brain 2020 13:51

    Content type: Research

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  11. Following publication of the original article [1], the authors reported errors in Figure 4.

    Authors: Yun-Fei Bai, Michelle Chiu, Elizabeth S. Chan, Peter Axerio-Cilies, Jie Lu, Linda Huh, Mary B. Connolly, Ilaria Guella, Matthew J. Farrer, Zhi-Qing David Xu, Lidong Liu, Michelle Demos and Yu Tian Wang

    Citation: Molecular Brain 2020 13:50

    Content type: Correction

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    The original article was published in Molecular Brain 2019 12:92

  12. Anterior cingulate cortex (ACC) plays important roles in sensory perception including pain and itch. Neurons in the ACC receive various neuromodulatory inputs from subcortical structures, including locus coeru...

    Authors: Kohei Koga, Akihiro Yamada, Qian Song, Xu-Hui Li, Qi-Yu Chen, Ren-Hao Liu, Jun Ge, Cheng Zhan, Hidemasa Furue, Min Zhuo and Tao Chen

    Citation: Molecular Brain 2020 13:49

    Content type: Research

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  14. Bone cancer pain (BCP) is one of the most common types of chronic cancer pain and its pathogenesis has not been fully understood. Long non-coding RNAs (lncRNAs) are new promising targets in the field of pain r...

    Authors: Xinran Hou, Yingqi Weng, Qulian Guo, Zhuofeng Ding, Jian Wang, Jiajia Dai, Anqi Wei and Zongbin Song

    Citation: Molecular Brain 2020 13:47

    Content type: Research

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  16. Understanding the connecting structure of brain network is the basis to reveal the principle of the brain function and elucidate the mechanism of brain diseases. Trans-synaptic tracing with neurotropic viruses...

    Authors: Kunzhang Lin, Xin Zhong, Min Ying, Lei Li, Sijue Tao, Xutao Zhu, Xiaobin He and Fuqiang Xu

    Citation: Molecular Brain 2020 13:45

    Content type: Methodology

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  17. A hallmark of classical conditioning is that conditioned stimulus (CS) must be tightly coupled with unconditioned stimulus (US), often requiring temporal overlap between the two, or a short gap of several seco...

    Authors: Fei Li, Chun-Hui Jia, Jun Huang, Guo-Qiang Bi and Pak-Ming Lau

    Citation: Molecular Brain 2020 13:44

    Content type: Micro report

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  18. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most common forms of hereditary cerebral small vessel diseases and is caused by mutations in NOTC...

    Authors: Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N. Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Raj N. Kalaria, Nobuya Inagaki, Ryosuke Takahashi, Mariko Harada-Shiba…

    Citation: Molecular Brain 2020 13:38

    Content type: Research

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  19. Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of cultured brain circuits to BDNF leads to ...

    Authors: Rossana Rauti, Giada Cellot, Paola D’Andrea, Andrea Colliva, Denis Scaini, Enrico Tongiorgi and Laura Ballerini

    Citation: Molecular Brain 2020 13:43

    Content type: Research

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  20. Active changes in neuronal DNA methylation and demethylation appear to act as controllers of synaptic scaling and glutamate receptor trafficking in learning and memory formation. DNA methyltransferases (DNMTs)...

    Authors: Qingnuan Kong, Ming Yu, Meng Zhang, Chuang Wei, Huating Gu, Shaoyang Yu, Wei Sun, Nan Li and Yu Zhou

    Citation: Molecular Brain 2020 13:42

    Content type: Micro report

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  22. Retinal Müller cells are highly polarized macroglial cells with accumulation of the aquaporin-4 (AQP4) water channel and the inwardly rectifying potassium channel Kir4.1 at specialized endfoot membrane domains ab...

    Authors: Shirin Katoozi, Shreyas B. Rao, Nadia Skauli, Stanley C. Froehner, Ole Petter Ottersen, Marvin E. Adams and Mahmood Amiry-Moghaddam

    Citation: Molecular Brain 2020 13:40

    Content type: Research

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  23. Information processing and memory formation in the brain relies on release of the main excitatory neurotransmitter glutamate from presynaptic axonal specialisations. The classical Hebbian paradigm of synaptic ...

    Authors: Olga Kopach, Kaiyu Zheng and Dmitri A. Rusakov

    Citation: Molecular Brain 2020 13:39

    Content type: Research

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    The Correction to this article has been published in Molecular Brain 2020 13:48

  24. In the white matter of the human cerebrum, the majority of cortico-cortical fibers are of short range, connecting neighboring cortical areas. U-fibers represent connections between neighboring areas and are lo...

    Authors: Mayuko Yoshino, Kengo Saito, Kanji Kawasaki, Toshihide Horiike, Yohei Shinmyo and Hiroshi Kawasaki

    Citation: Molecular Brain 2020 13:37

    Content type: Research

    Published on:

  25. Recent studies demonstrate that calcitonin gene-related peptide (CGRP) plays critical roles in migraine. Immunohistochemistry and in situ hybridization studies have shown that CGRP and its receptors are expres...

    Authors: Yinglu Liu, Qi-Yu Chen, Jung Hyun Lee, Xu-Hui Li, Shengyuan Yu and Min Zhuo

    Citation: Molecular Brain 2020 13:36

    Content type: Research

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  26. Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, an intracellular calcium channel. Studies from our and other’s lab have...

    Authors: Ren-wen Han, Zhi-peng Liu, Hong-ru Lin, Ao-wen Tian, Yun-fei Xiao, Jie Wei, Ke-yu Deng, Bing-xing Pan and Hong-bo Xin

    Citation: Molecular Brain 2020 13:35

    Content type: Research

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  28. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of cortical, brain stem and spinal motor neurons that leads to muscle weakness and death. A previous st...

    Authors: Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, Omid Haji-Ghassemi, Romane Idoux, Anna Liashenko, Ivana A. Souza, Yuriy Rzhepetskyy, Lubica Lacinova, Filip Van Petegem, Gerald W. Zamponi, Roger Pamphlett and Norbert Weiss

    Citation: Molecular Brain 2020 13:33

    Content type: Research

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  29. NMDA receptors are heteromeric complexes that contribute to excitatory synaptic transmission and plasticity. The presence of specific variants of GluN2 subunits in these complexes enables diversity in NMDA rec...

    Authors: Hadir Mahmoud, Newton Martin and Michael E. Hildebrand

    Citation: Molecular Brain 2020 13:31

    Content type: Micro report

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  30. Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles...

    Authors: Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth and Shiv Kumar Sharma

    Citation: Molecular Brain 2020 13:30

    Content type: Research

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  31. Tsukushi (TSK)—a small, secreted, leucine-rich-repeat proteoglycan—interacts with and regulates essential cellular signaling cascades. However, its functions in the mouse inner ear are unknown. In this study, ...

    Authors: Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song and Ryosei Minoda

    Citation: Molecular Brain 2020 13:29

    Content type: Research

    Published on:

  32. Primary cilia are centriole-derived sensory organelles that are present in most mammalian cells, including astrocytes and neurons. Evidence is emerging that astrocyte and neuronal primary cilia demonstrate a d...

    Authors: Ashley Sterpka, Juan Yang, Matthew Strobel, Yuxin Zhou, Connor Pauplis and Xuanmao Chen

    Citation: Molecular Brain 2020 13:28

    Content type: Research

    Published on:

  33. Calcium (Ca2+)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca2+-permeable if they lack the GluA2 subunit or if GluA...

    Authors: Lyndsey M. Konen, Amanda L. Wright, Gordon A. Royle, Gary P. Morris, Benjamin K. Lau, Patrick W. Seow, Raphael Zinn, Luke T. Milham, Christopher W. Vaughan and Bryce Vissel

    Citation: Molecular Brain 2020 13:27

    Content type: Research

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  34. The astrocyte brain-type fatty acid binding protein (Fabp7) gene expression cycles globally throughout mammalian brain, and is known to regulate sleep in multiple species, including humans. The mechanisms that co...

    Authors: Jason R. Gerstner and Georgios K. Paschos

    Citation: Molecular Brain 2020 13:26

    Content type: Micro report

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  36. Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-depen...

    Authors: Kazunari Onodera, Daisuke Shimojo, Yasuharu Ishihara, Masato Yano, Fuyuki Miya, Haruhiko Banno, Naoko Kuzumaki, Takuji Ito, Rina Okada, Bruno de Araújo Herculano, Manabu Ohyama, Mari Yoshida, Tatsuhiko Tsunoda, Masahisa Katsuno, Manabu Doyu, Gen Sobue…

    Citation: Molecular Brain 2020 13:18

    Content type: Research

    Published on:

  37. N-methyl-d-aspartate receptors (NMDARs) are excitatory glutamatergic receptors that are fundamental for many neuronal processes, including synaptic plasticity. NMDARs are comprised of four subunits derived from h...

    Authors: Vishaal Rajani, Ameet S. Sengar and Michael W. Salter

    Citation: Molecular Brain 2020 13:23

    Content type: Review

    Published on:

  38. The anterior cingulate cortex (ACC) serves as a critical hub for the anxiety and pain perception. The large-conductance Ca2+-activated potassium channels, or BKCa channels, are ubiquitously expressed throughout t...

    Authors: Huan Zhao, Qian Xue, Cong Li, Qingchuan Wang, Shichao Han, Yongsheng Zhou, Tao Yang, Yingli Xie, Hao Fu, Changbo Lu, Fancheng Meng, Ming Zhang, Yan Zhang, Xianglong Wu, Shengxi Wu, Min Zhuo…

    Citation: Molecular Brain 2020 13:22

    Content type: Research

    Published on:

  39. Amyloid beta (Aβ) deposition was demonstrated to be elevated in the brains of HIV-infected patients and associated with neurocognitive decline; however, the mechanisms of these processes are poorly understood....

    Authors: Ibolya E. András, Marta Garcia-Contreras, Christopher Yanick, Paola Perez, Brice Sewell, Leonardo Durand and Michal Toborek

    Citation: Molecular Brain 2020 13:21

    Content type: Research

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  40. Toll-like receptor 4 (TLR4) is a crucial receptor in neuroinflammation and apoptotic neuronal death, and increasing evidences indicated that β2-microglobulin (B2M) is thought to be a major contributor to age-r...

    Authors: Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen and Zongze Zhang

    Citation: Molecular Brain 2020 13:20

    Content type: Research

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  41. Synaptic proteins play an important role for the regulation of synaptic plasticity. Numerous studies have identified and revealed individual synaptic protein functions using protein overexpression or deletion....

    Authors: Hyoung-Gon Ko, Dong Ik Park, Ji Hyun Lee, Christoph W. Turck and Bong-Kiun Kaang

    Citation: Molecular Brain 2020 13:19

    Content type: Micro report

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  42. Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by memory loss and the presence of amyloid plaques and neurofibrillary tangles in the patients’ brains. In this study, we inv...

    Authors: Hyunju Kim, Bora Kim, Hye-Sun Kim and Joo-Youn Cho

    Citation: Molecular Brain 2020 13:17

    Content type: Research

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  44. Anxiety disorder is highly prevalent worldwide and represents a chronic and functionally disabling condition, with high levels of psychological stress characterized by cognitive and physiological symptoms. Sco...

    Authors: Li Luo, Ting Sun, Le Yang, An Liu, Qing-qing Liu, Qin-qin Tian, Yan Wang, Ming-gao Zhao and Qi Yang

    Citation: Molecular Brain 2020 13:15

    Content type: Research

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  45. Nociception is important perception that has harmful influence on daily life of humans. As to main pain management system, some descending pathways are called descending antinociceptive systems (DAS). As main ...

    Authors: Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Yuki Kambe, Junichi Sakaguchi, Honami Setoyama, Akihiro Yamanaka and Tomoyuki Kuwaki

    Citation: Molecular Brain 2020 13:14

    Content type: Research

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  46. Presynaptic active zone cytomatrix proteins are essential elements of neurotransmitter release machinery that govern neural transmission. Among active zone proteins, cytomatrix at the active zone-associated st...

    Authors: Akari Hagiwara, Shun Hamada, Yamato Hida and Toshihisa Ohtsuka

    Citation: Molecular Brain 2020 13:13

    Content type: Short report

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  47. Hippocampal GABAergic interneurons play key roles in regulating principal cell activity and plasticity. Interneurons located in stratum oriens/alveus (O/A INs) receive excitatory inputs from CA1 pyramidal cells a...

    Authors: André Kougioumoutzakis, Joe Guillaume Pelletier, Isabel Laplante, Abdessattar Khlaifia and Jean-Claude Lacaille

    Citation: Molecular Brain 2020 13:12

    Content type: Research

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  48. N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA. It has been reported that there is a stimulus-dependent regulation of m6A in the mammalian central nervous s...

    Authors: Jiangtao Yu, Yuxian Zhang, Haoli Ma, Rong Zeng, Ruining Liu, Pengcheng Wang, Xiaoqing Jin and Yan Zhao

    Citation: Molecular Brain 2020 13:11

    Content type: Research

    Published on:

  50. Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43), a DNA/RNA binding protein, is a pathological signature of amyotrophic lateral sclerosis (ALS). Missense mutations in the TARDBP gene are also found in...

    Authors: Seiji Watanabe, Kotaro Oiwa, Yuri Murata, Okiru Komine, Akira Sobue, Fumito Endo, Eiki Takahashi and Koji Yamanaka

    Citation: Molecular Brain 2020 13:8

    Content type: Micro report

    Published on:

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