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  1. Angiotensin (Ang)-converting-enzyme (ACE) 2 converts Ang II into Ang (1–7), which in turn acts on MAS receptors (ACE2/Ang (1–7)/MAS receptors pathway). This pathway has neuroprotective properties, making it a ...

    Authors: Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto and Koichi Tan-No
    Citation: Molecular Brain 2023 16:52
  2. Mice hippocampus contains three prominent subregions, CA1, CA3 and DG and is well regarded as an essential multiple task processor for learning, memory and cognition based on tremendous studies on these three ...

    Authors: Siqi Peng, Wenzhen Gu, Wenxiu Zhu, Yan Zhuang, Xiuqi Yang, Yaochen Lv, Sibie Meng, Wei Xie and Moyi Li
    Citation: Molecular Brain 2023 16:50
  3. The relationship between autism spectrum disorder (ASD) and dendritic spine abnormalities is well known, but it is unclear whether the deficits relate to specific neuron types and brain regions most relevant t...

    Authors: Lucia Celora, Fanny Jaudon, Carmela Vitale and Lorenzo A. Cingolani
    Citation: Molecular Brain 2023 16:49
  4. Delta-9-tetrahydrocannabinol (Δ9-THC) is known to produce systemic analgesia that involves CB1 and CB2 cannabinoid receptors. However, there is compelling evidence that Δ9-THC can potently inhibit Cav3.2T-type ca...

    Authors: Vinicius de Maria Gadotti, Flavia Tasmin Techera Antunes and Gerald W. Zamponi
    Citation: Molecular Brain 2023 16:47
  5. Social behavior emerges early in development, a time marked by the onset of neurodevelopmental disorders featuring social deficits, including autism spectrum disorder (ASD). Although social deficits are at the...

    Authors: Melina Matthiesen, Abdessattar Khlaifia, Carl Frank David Steininger Jr, Maryam Dadabhoy, Unza Mumtaz and Maithe Arruda-Carvalho
    Citation: Molecular Brain 2023 16:46
  6. High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may greatly depolarize dendritic membrane potential. The physiological significance of burst...

    Authors: Yoonsub Kim, Sooyun Kim, Won-Kyung Ho and Suk-Ho Lee
    Citation: Molecular Brain 2023 16:45
  7. Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha (α1–4) and β subunits. The GlyR subunits play major roles in the mammalian central nervous system, ranging from regulating simple s...

    Authors: Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie and Keizo Takao
    Citation: Molecular Brain 2023 16:44
  8. Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modulating their functions via ionotropic and G-protein coupled mechanisms. GABAergic interne...

    Authors: Simo Ojanen, Tatiana Kuznetsova, Zoia Kharybina, Vootele Voikar, Sari E. Lauri and Tomi Taira
    Citation: Molecular Brain 2023 16:43
  9. Dysregulation of HDAC4 expression and/or nucleocytoplasmic shuttling results in impaired neuronal morphogenesis and long-term memory in Drosophila melanogaster. A recent genetic screen for genes that interact in ...

    Authors: Silvia Schwartz, Sarah J Wilson, Tracy K Hale and Helen L Fitzsimons
    Citation: Molecular Brain 2023 16:42
  10. The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate ...

    Authors: Ji-Eun Bae, Soyoung Jang, Joon Bum Kim, Hyejin Hyung, Na Yeon Park, Yong Hwan Kim, So Hyun Kim, Seong Hyun Kim, Jin Min Ha, Gyeong Seok Oh, Kyuhee Park, Kwiwan Jeong, Jae Seon Jang, Doo Sin Jo, Pansoo Kim, Hyun-Shik Lee…
    Citation: Molecular Brain 2023 16:41
  11. Cooperation is a social behavior crucial for the survival of many species, including humans. Several experimental paradigms have been established to study cooperative behavior and related neural activity in di...

    Authors: Ke-Ming Zhang, Yan Shen, Chun-Hui Jia, Hao Wang, Guo-Qiang Bi and Pak-Ming Lau
    Citation: Molecular Brain 2023 16:40
  12. Stroke is a common cerebrovascular disease with great danger to public health. Educational inequality is a universal issue that influences populations’ stroke risk. This study aimed to investigate the causal r...

    Authors: Bangbei Wan, Ning Ma, Zhi Zhou and Weiying Lu
    Citation: Molecular Brain 2023 16:39
  13. Characterization of inter-regional interactions in brain is essential for understanding the mechanism relevant to normal brain function and neurological disease. The recently developed flexible micro (μ)-elect...

    Authors: Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi and Noriaki Ohkawa
    Citation: Molecular Brain 2023 16:38
  14. Profiling molecular expression in situ allows the integration of biomolecular and cellular features, enabling an in-depth understanding of biological systems. Multiplexed immunofluorescence methods can visuali...

    Authors: Wonjin Cho, Sehun Kim and Young-Gyun Park
    Citation: Molecular Brain 2023 16:37
  15. Increasing evidence indicates the major role of mitochondrial function in neurodegenerative disease. However, it is unclear whether mitochondrial dynamics directly affect postoperative neurocognitive disorder ...

    Authors: Zhibin Xiao, Xiajing Zhang, Guangyao Li, Li Sun, Jiangjing Li, Ziwei Jing, Qingya Qiu, Guangxiang He, Changjun Gao and Xude Sun
    Citation: Molecular Brain 2023 16:36
  16. Microglia, as macrophages in the brain, are responsible for immune responses and synaptic remodeling. Although the function of microglia is regulated by circadian rhythms, it is still unclear whether microglia...

    Authors: Futaba Matsui, Sho T. Yamaguchi, Riho Kobayashi, Shiho Ito, Sakimi Nagashima, Zhiwen Zhou and Hiroaki Norimoto
    Citation: Molecular Brain 2023 16:34
  17. FMRP, an RNA-binding protein, has previously shown to be involved in regulation of circadian rhythms in flies and mice. However, the molecular mechanism remains elusive. Here we demonstrate that core circadian...

    Authors: Xiangrong Tang, Jing Zhang, Xin Li, Ying Hu, Dengfeng Liu, Jia-Da Li and Renbin Lu
    Citation: Molecular Brain 2023 16:33
  18. The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission. Mice genetically deficient in 5-HTT expression have been used to study the physiological functions of 5...

    Authors: Hirotaka Shoji, Kazutaka Ikeda and Tsuyoshi Miyakawa
    Citation: Molecular Brain 2023 16:32
  19. Cognitive functions depend on the time of day in various organisms. Previously, we found that 24-h recognition memory performance of nocturnal mice changes diurnally through SCOP protein-dependent regulation. ...

    Authors: Kimiko Shimizu, Ken-ichi Inoue, Takao Oishi, Masahiko Takada, Yoshitaka Fukada and Hiroo Imai
    Citation: Molecular Brain 2023 16:31
  20. Neuronal voltage changes which are dependent on chloride transporters and channels are involved in forming neural functions during early development and maintaining their stability until adulthood. The intrace...

    Authors: Yanruo Huang, Qihang Wang, Yunsong Peng, Wenjie Du, Qi Wang, Jiangtao Qi, Zijian Hao and Yingwei Wang
    Citation: Molecular Brain 2023 16:30
  21. Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals are about to eat and drink. While the affective valence of taste signals is supposed to b...

    Authors: Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase, Takashi Nagashima, Mikiyasu Yamamoto, Haruhiko Bito, Sayaka Takemoto-Kimura, Toshihisa Ohtsuka and Ayako M. Watabe
    Citation: Molecular Brain 2023 16:28
  22. Nav1.8-positive afferent fibers are mostly nociceptors playing a role in mediating thermal and mechanical pain, but mechanoreceptors within these afferents have not been fully investigated. In this study, we g...

    Authors: Akihiro Yamada, Ayaka I. Yamada, Jennifer Ling, Hidemasa Furue, Wenqin Luo and Jianguo G. Gu
    Citation: Molecular Brain 2023 16:27
  23. Metabolites secreted by the gut microbiota may play an essential role in microbiota–gut–central nervous system crosstalk. In this study, we explored the changes occurring in the gut microbiota and their metabo...

    Authors: Ganggang Kong, Wenwu Zhang, Siyun Zhang, Jiewen Chen, kejun He, Changming Zhang, Xi Yuan and Baoshu Xie
    Citation: Molecular Brain 2023 16:26
  24. The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for t...

    Authors: Cristina Nuñez-Diaz, Dovilė Pocevičiūtė, Nina Schultz, Charlotte Welinder, Karl Swärd and Malin Wennström
    Citation: Molecular Brain 2023 16:25
  25. The prenylation of proteins is involved in a variety of biological functions. However, it remains unknown whether it plays an important role in the morphogenesis of the cerebellum. To address this question, we...

    Authors: Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen and Bin Xue
    Citation: Molecular Brain 2023 16:24
  26. Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case ...

    Authors: Guilherme M. Gomes, Julia Bär, Anna Karpova and Michael R. Kreutz
    Citation: Molecular Brain 2023 16:23
  27. Melanoma-associated antigen D1 (Maged1) has critical functions in the central nervous system in both developmental and adult stages. Loss of Maged1 in mice has been linked to depression, cognitive disorder, an...

    Authors: Jie Wang, Sheng-Ye Xu, Zhi-Yuan Ye, Zhou-Na Sun, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei-Yan You and Jun Gao
    Citation: Molecular Brain 2023 16:22

    The Correction to this article has been published in Molecular Brain 2024 17:6

  28. Electromagnetic pulse (EMP), a unique type of electromagnetic radiation, may induce diverse neuropsychiatric disorders, such as irritability, hyperkinesis, retardation of learning and memory. However, the unde...

    Authors: Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing and Tao Chen
    Citation: Molecular Brain 2023 16:21
  29. NLGN4X was identified as a single causative gene of rare familial nonsyndromic autism for the first time. It encodes the postsynaptic membrane protein Neuroligin4 (NLGN4), the functions and roles of which, howeve...

    Authors: Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki and Atsuo Nakayama
    Citation: Molecular Brain 2023 16:20
  30. A growing body of evidence suggests that intractable pain reduces both the quality of life and survival in cancer patients. In the present study, we evaluated whether chronic pain stimuli could directly affect...

    Authors: Kenichi Tanaka, Takashige Kondo, Michiko Narita, Takeru Muta, Sara Yoshida, Daisuke Sato, Yukari Suda, Yusuke Hamada, Takatsune Shimizu, Naoko Kuzumaki and Minoru Narita
    Citation: Molecular Brain 2023 16:19
  31. A growing body of evidence suggests that excess stress could aggravate tumor progression. The paraventricular nucleus (PVN) of the hypothalamus plays an important role in the adaptation to stress because the h...

    Authors: Sara Yoshida, Yusuke Hamada, Michiko Narita, Daisuke Sato, Kenichi Tanaka, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Hideki Tamura, Kazunori Aoki, Naoko Kuzumaki and Minoru Narita
    Citation: Molecular Brain 2023 16:18
  32. It is well documented that 17β estradiol (E2) regulates excitatory synaptic transmission at hippocampal Shaffer-collateral (SC)-CA1 synapses, via activation of the classical estrogen receptors (ERα and ERβ). H...

    Authors: Leigh Clements, Amy Alexander, Kirsty Hamilton, Andrew Irving and Jenni Harvey
    Citation: Molecular Brain 2023 16:16
  33. Our previous study showed that the flotillin level is decreased in the blood of patients with Alzheimer’s disease (AD) when compared to that of patients with non-AD and vascular dementia; however, the molecula...

    Authors: Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga and Makoto Michikawa
    Citation: Molecular Brain 2023 16:15
  34. Status epilepticus (SE) in humans is characterized by prolonged convulsive seizures that are generalized and often difficult to control. The current antiseizure drugs (ASDs) aim to stop seizures quickly enough...

    Authors: Nelufar Yasmen, Madison N. Sluter, Lexiao Li, Ying Yu and Jianxiong Jiang
    Citation: Molecular Brain 2023 16:14
  35. The central nervous system is organized into different neural circuits, each with particular functions and properties. Studying neural circuits is essential to understanding brain function and neuronal disease...

    Authors: Sukmin Han, Seokyoung Bang, Hong Nam Kim, Nakwon Choi and Sung Hyun Kim
    Citation: Molecular Brain 2023 16:13
  36. The N-methyl-d-aspartate receptors (NRs) in hippocampal CA3 are crucial for the synaptic transmission and plasticity within the CA3 recurrent circuit, which supports the hippocampal functions, such as pattern com...

    Authors: Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi and Naoya Oishi
    Citation: Molecular Brain 2023 16:12

    The Correction to this article has been published in Molecular Brain 2023 16:29

  37. Although dyslipidemia in the brain has been implicated in neurodegenerative disorders, the molecular mechanisms underlying its pathogenesis have been largely unclear. PDZD8 is a lipid transfer protein and mice...

    Authors: Yuji Kurihara, Kotone Mitsunari, Nagi Mukae, Hirotaka Shoji, Tsuyoshi Miyakawa and Michiko Shirane
    Citation: Molecular Brain 2023 16:11
  38. The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in ...

    Authors: Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles and Nahum Sonenberg
    Citation: Molecular Brain 2023 16:9
  39. Saltatory conduction is the propagation of action potentials along myelinated nerves, which enables fast propagation through the node of Ranvier. Recently, we demonstrated that K2P channels, TWIK-related K+ chann...

    Authors: Hirosato Kanda, Koichi Noguchi and Yi Dai
    Citation: Molecular Brain 2023 16:8
  40. Studies of mouse models of Alzheimer's disease (AD) have demonstrated that nitric oxide synthase 2 (NOS2) is involved in AD pathology. However, the effects of NOS2 on the pathology of Parkinson’s disease (PD) ...

    Authors: Jieun Kim, Jung-Youn Han, Yujeong Lee, Kipom Kim, Young Pyo Choi, Sehyun Chae and Hyang-Sook Hoe
    Citation: Molecular Brain 2023 16:7
  41. Synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia with tau pathology (FTD-tau), a group of primary ta...

    Authors: Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen and Jürgen Götz
    Citation: Molecular Brain 2023 16:6
  42. Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focuse...

    Authors: Si-Bo Zhou, Man Xue, Weiqi Liu, Yu-Xin Chen, Qi-Yu Chen, Jing-Shan Lu, Jinjun Wang, Keqiang Ye, Xu-Hui Li and Min Zhuo
    Citation: Molecular Brain 2023 16:4
  43. Pain is known to have sensory and affective components. The sensory pain component is encoded by neurons in the primary somatosensory cortex (S1), whereas the emotional or affective pain experience is in large...

    Authors: Guanghao Sun, Michael McCartin, Weizhuo Liu, Qiaosheng Zhang, George Kenefati, Zhe Sage Chen and Jing Wang
    Citation: Molecular Brain 2023 16:3
  44. The 14-3-3 protein family with seven isoforms found in mammals is widely expressed in the brain and plays various roles in cellular processes. Several studies have reported that 14-3-3γ, one of the 14-3-3 prot...

    Authors: Eunsil Cho, Jinsil Park, Eun Mi Hwang, Hyung Wook Kim and Jae-Yong Park
    Citation: Molecular Brain 2023 16:2

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