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  1. Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel NaV1.7 is under the control of SUMOylated collapsin response me...

    Authors: Kimberly Gomez, Dongzhi Ran, Cynthia L. Madura, Aubin Moutal and Rajesh Khanna

    Citation: Molecular Brain 2021 14:20

    Content type: Research

    Published on:

  2. Writer’s cramp (WC) is a task-specific focal dystonia that occurs selectively in the hand and arm during writing. Previous studies have shown a role for genetics in the pathology of task-specific focal dystoni...

    Authors: Miaozhen Huang, Esther A. R. Nibbeling, Tjerk J. Lagrand, Ivana A. Souza, Justus L. Groen, Maria A. Gandini, Fang-Xiong Zhang, Johannes H. T. M. Koelman, Noam Adir, Richard J. Sinke, Gerald W. Zamponi, Marina A. J. Tijssen and Dineke S. Verbeek

    Citation: Molecular Brain 2021 14:18

    Content type: Micro report

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  3. The hypothalamus links the nervous system to the endocrine system and plays a crucial role in maintaining the human body's homeostasis. This study aims to investigate the resting state functional connectivity ...

    Authors: Jian Kong, Yiting Huang, Jiao Liu, Siyi Yu, Cheng Ming, Helen Chen, Georgia Wilson, William F. Harvey, Wen Li and Chenchen Wang

    Citation: Molecular Brain 2021 14:17

    Content type: Research

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  4. Lysosomal dysfunction is a central pathway associated with Parkinson’s disease (PD) pathogenesis. Haploinsufficiency of the lysosomal hydrolase GBA (encoding glucocerebrosidase (GCase)) is one of the largest gene...

    Authors: Ria Thomas, Elizabeth B. Moloney, Zachary K. Macbain, Penelope J. Hallett and Ole Isacson

    Citation: Molecular Brain 2021 14:16

    Content type: Research

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  5. Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized that the chronic pruritus may result from sensitization of itch-signaling pathways but the mechanisms rem...

    Authors: Tao Wang, Jin Tao, Yehong Fang and Chao Ma

    Citation: Molecular Brain 2021 14:15

    Content type: Research

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  6. Mitochondrial movement in neurons is finely regulated to meet the local demand for energy and calcium buffering. Elaborate transport machinery including motor complexes is required to deliver and localize mito...

    Authors: Bo Kyoung Suh, Seol-Ae Lee, Cana Park, Yeongjun Suh, Soo Jeong Kim, Youngsik Woo, Truong Thi My Nhung, Su Been Lee, Dong Jin Mun, Bon Seong Goo, Hyun Sun Choi, So Jung Kim and Sang Ki Park

    Citation: Molecular Brain 2021 14:14

    Content type: Research

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  8. Schizophrenia (SZ) is a devastating brain disease that affects about 1% of world population. Among the top genetic associations, zinc finger protein 804A (ZNF804A) gene encodes a zinc finger protein, associated w...

    Authors: Fengping Dong, Joseph Mao, Miranda Chen, Joy Yoon and Yingwei Mao

    Citation: Molecular Brain 2021 14:12

    Content type: Research

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  10. The neurotrophin Brain-derived neurotrophic factor (BDNF) is encoded by multiple bipartite transcripts. Each BDNF transcript is composed by one out of 11 alternatively spliced exons containing the 5′untranslat...

    Authors: Andrea Colliva and Enrico Tongiorgi

    Citation: Molecular Brain 2021 14:10

    Content type: Short report

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  11. Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to ...

    Authors: Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz and Anna Karpova

    Citation: Molecular Brain 2021 14:9

    Content type: Short report

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  13. Psychiatric disorders are affected by genetic susceptibility and environmental adversities. Therefore, the regulation of gene expression under certain environments, such as stress, is a key issue in psychiatri...

    Authors: Jungyoung Park, Joonhee Lee, Koeul Choi and Hyo Jung Kang

    Citation: Molecular Brain 2021 14:7

    Content type: Micro report

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  14. As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. Howe...

    Authors: So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo and Dong-Hyung Cho

    Citation: Molecular Brain 2021 14:6

    Content type: Micro report

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  15. Reduced expression of glutamate decarboxylase 67 (GAD67), encoded by the Gad1 gene, is a consistent finding in postmortem brains of patients with several psychiatric disorders, including schizophrenia, bipolar di...

    Authors: Shigeo Miyata, Toshikazu Kakizaki, Kazuyuki Fujihara, Hideru Obinata, Touko Hirano, Junichi Nakai, Mika Tanaka, Shigeyoshi Itohara, Masahiko Watanabe, Kenji F. Tanaka, Manabu Abe, Kenji Sakimura and Yuchio Yanagawa

    Citation: Molecular Brain 2021 14:5

    Content type: Research

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  16. A novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia. This mutation leads to a s...

    Authors: Eder Gambeta, Maria A. Gandini, Ivana A. Souza, Laurent Ferron and Gerald W. Zamponi

    Citation: Molecular Brain 2021 14:4

    Content type: Short report

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  17. To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.

    Authors: Xiao Liang, ShiQiang Cheng, Jing Ye, XiaoMeng Chu, Yan Wen, Li Liu, Xin Qi, YuMeng Jia and Feng Zhang

    Citation: Molecular Brain 2021 14:3

    Content type: Research

    Published on:

  18. Formation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs ...

    Authors: Min Soo Kang and Jin-Hee Han

    Citation: Molecular Brain 2021 14:2

    Content type: Micro report

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  19. CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional...

    Authors: Dong Il Choi, Myeongwon Kim, Somi Kim, Nam-Kyung Yu, Chuljung Kwak, Hyunhyo Seo, Kyungmin Lee and Bong-Kiun Kaang

    Citation: Molecular Brain 2021 14:1

    Content type: Micro report

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  20. Corticogenesis is one of the most critical and complicated processes during embryonic brain development. Any slight impairment in corticogenesis could cause neurodevelopmental disorders such as Fragile X syndr...

    Authors: Cristine R. Casingal, Takako Kikkawa, Hitoshi Inada, Yukio Sasaki and Noriko Osumi

    Citation: Molecular Brain 2020 13:167

    Content type: Research

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  21. Disturbances of attention are a common behavioral feature associated with neuropsychiatric disorders with largely unknown underlying causes. We previously developed an object-based attention test (OBAT) as a s...

    Authors: Bolati Wulaer, Kazuo Kunisawa, Hisayoshi Kubota, Willy Jaya Suento, Kuniaki Saito, Akihiro Mouri and Toshitaka Nabeshima

    Citation: Molecular Brain 2020 13:171

    Content type: Micro report

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  22. Immune molecules, such as cytokines, complement, and major histocompatibility complex (MHC) proteins, in the central nervous system are often associated with neuropsychiatric disorders. Neuronal MHC class I (M...

    Authors: Bolati Wulaer, Kazuhiro Hada, Akira Sobue, Norimichi Itoh, Toshitaka Nabeshima, Taku Nagai and Kiyofumi Yamada

    Citation: Molecular Brain 2020 13:170

    Content type: Research

    Published on:

  23. The brain is composed of cells having distinct genomic DNA sequences that arise post-zygotically, known as somatic genomic mosaicism (SGM). One form of SGM is aneuploidy—the gain and/or loss of chromosomes—whi...

    Authors: Whitney S. McDonald, Kyoko Miyamoto, Richard Rivera, Grace Kennedy, Beatriz S. V. Almeida, Marcy A. Kingsbury and Jerold Chun

    Citation: Molecular Brain 2020 13:169

    Content type: Research

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  24. Dysfunctional dendritic arborization is a key feature of many developmental neurological disorders. Across various human brain regions, basal dendritic complexity is known to increase along a caudal-to-rostral...

    Authors: Brian D. Swinehart, Katherine M. Bland, Z. Logan Holley, Andrew J. Lopuch, Zachary O. Casey, Christopher J. Handwerk and George S. Vidal

    Citation: Molecular Brain 2020 13:168

    Content type: Short report

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  25. The low-density lipoprotein receptor-related protein 4 (LRP4) is essential for inducing the neuromuscular junction (NMJ) formation in muscle fibers, and LRP4 plays a critical role in dendritic development and ...

    Authors: Min Yan, Amin Guo, Peng Chen, Hongyang Jing, Dongyan Ren, Yanzi Zhong, Yongqiang Wu, Erkang Fei, Xinsheng Lai, Suqi Zou and Shunqi Wang

    Citation: Molecular Brain 2020 13:166

    Content type: Research

    Published on:

  27. Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in t...

    Authors: Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan and Li Zeng

    Citation: Molecular Brain 2020 13:164

    Content type: Research

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  28. Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel CaV3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountere...

    Authors: Naoyuki Hara, Hiroyuki Morino, Yukiko Matsuda, Kenichi Satoh, Kouichi Hashimoto, Hirofumi Maruyama and Hideshi Kawakami

    Citation: Molecular Brain 2020 13:163

    Content type: Research

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  29. Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor o...

    Authors: Zhuxi Liu, Caiqin Li, Xuelian Fan, Yifang Kuang, Xu Zhang, Lei Chen, Jinjing Song, Ying Zhou, Eiki Takahashi, Guang He and Weidong Li

    Citation: Molecular Brain 2020 13:162

    Content type: Short report

    Published on:

  30. Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we further explore the presynaptic role of CCL2. Behavioral experimen...

    Authors: Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo and Rou-Gang Xie

    Citation: Molecular Brain 2020 13:161

    Content type: Research

    Published on:

  31. CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 muta...

    Authors: Atsuki Kawamura, Yoshifumi Abe, Fumiko Seki, Yuta Katayama, Masaaki Nishiyama, Norio Takata, Kenji F. Tanaka, Hideyuki Okano and Keiichi I. Nakayama

    Citation: Molecular Brain 2020 13:160

    Content type: Research

    Published on:

  32. Paranodal axoglial junctions are essential for rapid nerve conduction and the organization of axonal domains in myelinated axons. Neurofascin155 (Nfasc155) is a glial cell adhesion molecule that is also requir...

    Authors: Kazuo Kunisawa, Nobuhiko Hatanaka, Takeshi Shimizu, Kenta Kobayashi, Yasuyuki Osanai, Akihiro Mouri, Qian Shi, Manzoor A. Bhat, Atsushi Nambu and Kazuhiro Ikenaka

    Citation: Molecular Brain 2020 13:159

    Content type: Short report

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  33. Neuropathic pain induced by a nerve injury can lead to chronic pain. Recent studies have reported hyperactive neural activities in the nociceptive-related area of the brain as a result of chronic pain. Althoug...

    Authors: Myeounghoon Cha, Songyeon Choi, Kyeongmin Kim and Bae Hwan Lee

    Citation: Molecular Brain 2020 13:158

    Content type: Research

    Published on:

  34. We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a fu...

    Authors: Won-Mo Jung, Ye-Seul Lee, In-Seon Lee, Christian Wallraven, Yeonhee Ryu and Younbyoung Chae

    Citation: Molecular Brain 2020 13:157

    Content type: Research

    Published on:

  35. Long-term memory formation is supported by functional and structural changes of neuronal networks, which rely on de novo gene transcription and protein synthesis. The modulation of the neuronal transcriptome i...

    Authors: David V. C. Brito, Kubra Gulmez Karaca, Janina Kupke, Lukas Frank and Ana M. M. Oliveira

    Citation: Molecular Brain 2020 13:156

    Content type: Research

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  36. Olig2 transcription factor is essential for the maintenance of neural progenitor cells (NPCs) in the pMN domain and their sequential specification into motor neurons (MNs) and oligodendrocyte precursor cells (OPC...

    Authors: Min Jiang, Dan Yu, Binghua Xie, Hao Huang, Wenwen Lu, Mengsheng Qiu and Zhong-Min Dai

    Citation: Molecular Brain 2020 13:155

    Content type: Micro report

    Published on:

  37. Long interspersed element-1 (LINE-1/L1) is the only autonomous transposable element in the human genome that currently mobilises in both germline and somatic tissues. Recent studies have identified correlation...

    Authors: Abigail L. Savage, Ana Illera Lopez, Alfredo Iacoangeli, Vivien J. Bubb, Bradley Smith, Claire Troakes, Nada Alahmady, Sulev Koks, Gerald G. Schumann, Ammar Al-Chalabi and John P. Quinn

    Citation: Molecular Brain 2020 13:154

    Content type: Research

    Published on:

  38. Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl2 is not only a hypoxia-mimetic reagent but also an...

    Authors: Han-Byeol Kim, Ji-Young Yoo, Seung-Yeon Yoo, Jun-Ho Lee, Wonseok Chang, Hye-Sun Kim, Tai-Kyoung Baik and Ran-Sook Woo

    Citation: Molecular Brain 2020 13:153

    Content type: Research

    Published on:

  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kohei Koga, Akihiro Yamada, Qian Song, Xu-Hui Li, Qi-Yu Chen, Ren-Hao Liu, Jun Ge, Cheng Zhan, Hidemasa Furue, Min Zhuo and Tao Chen

    Citation: Molecular Brain 2020 13:152

    Content type: Correction

    Published on:

    The original article was published in Molecular Brain 2020 13:49

  40. Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline with accumulation of amyloid beta (Aβ) and neurofibrillary tangles that usually begins 15–30 years before...

    Authors: Md. Ali Bin Saifullah, Okiru Komine, Yutao Dong, Kazuya Fukumoto, Akira Sobue, Fumito Endo, Takashi Saito, Takaomi C. Saido, Koji Yamanaka and Hiroyuki Mizoguchi

    Citation: Molecular Brain 2020 13:147

    Content type: Research

    Published on:

  41. The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and fu...

    Authors: Camille Dumon, Yasmine Belaidouni, Diabe Diabira, Suzanne M. Appleyard, Gary A. Wayman and Jean-Luc Gaiarsa

    Citation: Molecular Brain 2020 13:151

    Content type: Short report

    Published on:

  42. The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Ba...

    Authors: Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos and Javier Garzón-Niño

    Citation: Molecular Brain 2020 13:150

    Content type: Research

    Published on:

  43. Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel a...

    Authors: Vendula Ficelova, Ivana A. Souza, Leos Cmarko, Maria A. Gandini, Robin N. Stringer, Gerald W. Zamponi and Norbert Weiss

    Citation: Molecular Brain 2020 13:149

    Content type: Micro report

    Published on:

  44. Neuronal activity-regulated gene transcription underlies plasticity-dependent changes in the molecular composition and structure of neurons. A large number of genes regulated by different neuronal plasticity i...

    Authors: Johanna Denkena, Andrea Zaisser, Barbara Merz, Bertram Klinger, Dietmar Kuhl, Nils Blüthgen and Guido Hermey

    Citation: Molecular Brain 2020 13:148

    Content type: Research

    Published on:

  45. Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give r...

    Authors: Michiko Shirane, Hirotaka Shoji, Yutaka Hashimoto, Hiroyuki Katagiri, Shizuka Kobayashi, Toshiya Manabe, Tsuyoshi Miyakawa and Keiichi I. Nakayama

    Citation: Molecular Brain 2020 13:146

    Content type: Research

    Published on:

  46. Activity-dependent local protein synthesis is critical for synapse-specific, persistent plasticity. Abnormalities in local protein synthesis have been implicated in psychiatric disorders. We have recently iden...

    Authors: Alan Jung Park, Mahesh Shivarama Shetty, Jay M. Baraban and Ted Abel

    Citation: Molecular Brain 2020 13:145

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Brain 2021 14:48

  47. Itch is defined as an unpleasant sensation that provokes a desire to scratch. Our understanding of neuronal circuits for itch information transmission and processing in the spinal dorsal horn (SDH) has progres...

    Authors: Keisuke Koga, Yuto Shiraishi, Ryo Yamagata, Hidetoshi Tozaki-Saitoh, Miho Shiratori-Hayashi and Makoto Tsuda

    Citation: Molecular Brain 2020 13:144

    Content type: Research

    Published on:

  48. Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stres...

    Authors: Madhuvika Murugan, Jiaying Zheng, Gongxiong Wu, Rochelle Mogilevsky, Xin Zheng, Peiwen Hu, Junfang Wu and Long-Jun Wu

    Citation: Molecular Brain 2020 13:143

    Content type: Research

    Published on:

  49. To prevent or delay the onset of Alzheimer’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rar...

    Authors: Karissa Barthelson, Stephen Martin Pederson, Morgan Newman and Michael Lardelli

    Citation: Molecular Brain 2020 13:142

    Content type: Research

    Published on:

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