Skip to main content

Articles

Page 23 of 27

  1. Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maint...

    Authors: Michael S Sidorov, Benjamin D Auerbach and Mark F Bear
    Citation: Molecular Brain 2013 6:15
  2. Matrix metalloproteinases are important factors in the molecular mechanisms leading to neuronal injury in many neurological disorders. Matrix metalloproteinase (MMP)-9 is up-regulated after cerebral ischemia a...

    Authors: Kimberly E Hawkins, Kelly M DeMars, Changjun Yang, Gary A Rosenberg and Eduardo Candelario-Jalil
    Citation: Molecular Brain 2013 6:14
  3. Hippocampal N-methyl-D-aspartate receptor (NMDAR) is required for spatial working memory. Although evidence from genetic manipulation mice suggests an important role of hippocampal NMDAR NR2B subunits (NR2B-NM...

    Authors: Xue-Han Zhang, Shu-Su Liu, Feng Yi, Min Zhuo and Bao-Ming Li
    Citation: Molecular Brain 2013 6:13
  4. Synaptosomal-associated protein, 25 kDa (SNAP-25) regulates the exocytosis of neurotransmitters. Growing evidence suggests that SNAP-25 is involved in neuropsychiatric disorders, such as schizophrenia, attenti...

    Authors: Koji Ohira, Katsunori Kobayashi, Keiko Toyama, Hironori K Nakamura, Hirotaka Shoji, Keizo Takao, Rika Takeuchi, Shun Yamaguchi, Masakazu Kataoka, Shintaro Otsuka, Masami Takahashi and Tsuyoshi Miyakawa
    Citation: Molecular Brain 2013 6:12
  5. The editors of Molecular Brain would like to thank all our reviewers who have contributed to the journal in Volume 5 (2012).

    Authors: Tim Bliss, Bong-Kiun Kaang and Min Zhuo
    Citation: Molecular Brain 2013 6:7
  6. Pavlovian fear conditioning is a classical form of associative learning, which depends on associative synaptic plasticity in the amygdala. Recent findings suggest that the central amygdala (CeA) plays an activ...

    Authors: Ayako M Watabe, Toshitaka Ochiai, Masashi Nagase, Yukari Takahashi, Masaru Sato and Fusao Kato
    Citation: Molecular Brain 2013 6:11
  7. CaMKII is a major synaptic protein that is activated during the induction of long-term potentiation (LTP) by the Ca2+ influx through NMDARs. This activation is required for LTP induction, but the role of the kina...

    Authors: Magdalena Sanhueza and John Lisman
    Citation: Molecular Brain 2013 6:10
  8. Group I metabotropic glutamate receptors (mGluR) are coupled via Gαq/11 to the activation of phospholipase Cβ, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. In a...

    Authors: Maryse Paquet, Fabiola M Ribeiro, Jennifer Guadagno, Jessica L Esseltine, Stephen SG Ferguson and Sean P Cregan
    Citation: Molecular Brain 2013 6:9
  9. Opioids are associated with wide inter-individual variability in the analgesic response and a narrow therapeutic index. This may be partly explained by the presence of single nucleotide polymorphisms (SNPs) in...

    Authors: Annica Rhodin, Alfhild Grönbladh, Harumi Ginya, Kent W Nilsson, Andreas Rosenblad, Qin Zhou, Mats Enlund, Mathias Hallberg, Torsten Gordh and Fred Nyberg
    Citation: Molecular Brain 2013 6:8
  10. Neuronal activity alters calcium ion (Ca2+) dynamics in astrocytes, but the physiologic relevance of these changes is controversial. To examine this issue further, we generated an inducible transgenic mouse model...

    Authors: Mika Tanaka, Pei-Yu Shih, Hiroshi Gomi, Takamasa Yoshida, Junichi Nakai, Reiko Ando, Teiichi Furuichi, Katsuhiko Mikoshiba, Alexey Semyanov and Shigeyoshi Itohara
    Citation: Molecular Brain 2013 6:6
  11. Astrocytes regulate neuronal excitability and synaptic activity by releasing gliotransmitters such as glutamate. Our recent study demonstrated that astrocytes release glutamate upon GPCR activation via Ca2+ activ...

    Authors: Kyung-Seok Han, Junsung Woo, Hyungju Park, Bong-June Yoon, Sukwoo Choi and C Justin Lee
    Citation: Molecular Brain 2013 6:4
  12. The transplantation of neural stem/progenitor cells (NS/PCs) at the sub-acute phase of spinal cord injury, but not at the chronic phase, can promote functional recovery. However, the reasons for this differenc...

    Authors: Soraya Nishimura, Akimasa Yasuda, Hiroki Iwai, Morito Takano, Yoshiomi Kobayashi, Satoshi Nori, Osahiko Tsuji, Kanehiro Fujiyoshi, Hayao Ebise, Yoshiaki Toyama, Hideyuki Okano and Masaya Nakamura
    Citation: Molecular Brain 2013 6:3
  13. Loss of a sensory input causes the hypersensitivity in other modalities. In addition to cross-modal plasticity, the sensory cortices without receiving inputs undergo the plastic changes. It is not clear how th...

    Authors: Guanjun Zhang, Zilong Gao, Sudong Guan, Yan Zhu and Jin-Hui Wang
    Citation: Molecular Brain 2013 6:2
  14. Trigeminal neuropathic pain attacks can be excruciating for patients, even after being lightly touched. Although there are rodent trigeminal nerve research models to study orofacial pain, few models have been ...

    Authors: Fei Ma, Liping Zhang, Danielle Lyons and Karin N Westlund
    Citation: Molecular Brain 2012 5:44
  15. Postsynaptic density (PSD)-95-like membrane-associated guanylate kinases (PSD-MAGUKs) are scaffold proteins in PSDs that cluster signaling molecules near NMDA receptors. PSD-MAGUKs share a common domain struct...

    Authors: Hitoshi Nagura, Yasuyuki Ishikawa, Katsunori Kobayashi, Keizo Takao, Tomo Tanaka, Kouki Nishikawa, Hideki Tamura, Sadao Shiosaka, Hidenori Suzuki, Tsuyoshi Miyakawa, Yoshinori Fujiyoshi and Tomoko Doi
    Citation: Molecular Brain 2012 5:43
  16. Insulin-like growth factor 2 (Igf2) is a paternally expressed imprinted gene regulating fetal growth, playing an integral role in the development of many tissues including the brain. The parent-of-origin specific...

    Authors: Ruth Pidsley, Cathy Fernandes, Joana Viana, Jose L Paya-Cano, Lin Liu, Rebecca G Smith, Leonard C Schalkwyk and Jonathan Mill
    Citation: Molecular Brain 2012 5:42
  17. Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positiv...

    Authors: Ki-Jun Yoon, Hye-Ryeon Lee, Yong Sang Jo, Kyongman An, Sang-Yong Jung, Min-Woo Jeong, Seok-Kyu Kwon, Nam-Shik Kim, Hyun-Woo Jeong, Seo-Hee Ahn, Kyong-Tai Kim, Kyungmin Lee, Eunjoon Kim, Joung-Hun Kim, June-Seek Choi, Bong-Kiun Kaang…
    Citation: Molecular Brain 2012 5:40
  18. Glutamate is the major transmitter that mediates the principal form of excitatory synaptic transmission in the brain. It has been well established that glutamate is released via Ca2+-dependent exocytosis of gluta...

    Authors: Soo-Jin Oh, Kyung-Seok Han, Hyungju Park, Dong ho Woo, Hye Yun Kim, Stephen F Traynelis and C Justin Lee
    Citation: Molecular Brain 2012 5:38
  19. Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the

    Authors: Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Masato Koike, Naoko Kuzumaki, Hideki Hayakawa, Tomoko Nihira, Tetsuro Kobayashi, Manabu Ohyama, Shigeto Sato, Masashi Takanashi, Manabu Funayama, Akiyoshi Hirayama, Tomoyoshi Soga, Takako Hishiki, Makoto Suematsu…
    Citation: Molecular Brain 2012 5:35
  20. Axonopathy is critical in the early pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Axonal swellings such as globules and spheroids are a dis...

    Authors: Akio Sekigawa, Masayo Fujita, Kazunari Sekiyama, Yoshiki Takamatsu, Taku Hatano, Edward Rockenstein, Albert R La Spada, Eliezer Masliah and Makoto Hashimoto
    Citation: Molecular Brain 2012 5:34
  21. GABA, the major inhibitory neurotransmitter in CNS, has been demonstrated to paradoxically produce excitation even in mature brain. However activity-dependent form of GABA excitation in cortical neurons has no...

    Authors: Jaekwang Lee, Junsung Woo, Oleg V Favorov, Mark Tommerdahl, C Justin Lee and Barry L Whitsel
    Citation: Molecular Brain 2012 5:33
  22. Memories are stored within neuronal ensembles in the brain. Modern genetic techniques can be used to not only visualize specific neuronal ensembles that encode memories (e.g., fear, craving) but also to select...

    Authors: Masanori Sakaguchi and Yasunori Hayashi
    Citation: Molecular Brain 2012 5:32
  23. Mercury is a well-known neurotoxin implicated in a wide range of neurological or psychiatric disorders including autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, mood ...

    Authors: Fenglian Xu, Svetlana Farkas, Simone Kortbeek, Fang-Xiong Zhang, Lina Chen, Gerald W Zamponi and Naweed I Syed
    Citation: Molecular Brain 2012 5:30
  24. In the olfactory system of malacostracan crustaceans, axonal input from olfactory receptor neurons associated with aesthetascs on the animal’s first pair of antennae target primary processing centers in the me...

    Authors: Marta A Polanska, Oksana Tuchina, Hans Agricola, Bill S Hansson and Steffen Harzsch
    Citation: Molecular Brain 2012 5:29
  25. Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that is caused by the expansion of a polyglutamine (polyQ) stretch within Huntingtin (htt), the protein product of the HD gene. Alth...

    Authors: Shuqiu Zheng, Nima Ghitani, Jessica S Blackburn, Jeh-Ping Liu and Scott O Zeitlin
    Citation: Molecular Brain 2012 5:28
  26. Fragile X syndrome is caused by lack of fragile X mental retardation protein (FMRP) due to silencing of the FMR1 gene. The metabotropic glutamate receptors (mGluRs) in the central nervous system contribute to ...

    Authors: Hansen Wang, Yoshikazu Morishita, Daiki Miura, Jose R Naranjo, Satoshi Kida and Min Zhuo
    Citation: Molecular Brain 2012 5:27
  27. Action potentials at the neurons and graded signals at the synapses are primary codes in the brain. In terms of their functional interaction, the studies were focused on the influence of presynaptic spike patt...

    Authors: Jiandong Yu, Hao Qian and Jin-Hui Wang
    Citation: Molecular Brain 2012 5:26
  28. The Notch signaling pathway has been shown to be involved in the development of the nervous system. Recent studies showed that Notch receptors and ligands are also expressed in the nervous system of adult anim...

    Authors: Yan-Yan Sun, Li Li, Xiao-Hua Liu, Nan Gu, Hai-Long Dong and Lize Xiong
    Citation: Molecular Brain 2012 5:23
  29. There is mounting evidence for a neurodevelopmental basis for disorders such as autism and schizophrenia, in which prenatal or early postnatal events may influence brain development and predispose the young to...

    Authors: Caroline M Forrest, Omari S Khalil, Mazura Pisar, Robert A Smith, Lynda Gail Darlington and Trevor W Stone
    Citation: Molecular Brain 2012 5:22
  30. The most frequent pain in patients with metastatic breast and prostate cancer is bone pain, which can be severe and difficult to treat. The mechanisms underlying this pain remain unclear. Here we investigated ...

    Authors: Xiao-Wei Wang, Shan Hu, Qi-Liang Mao-Ying, Qian Li, Chang-Jiang Yang, Hui Zhang, Wen-Li Mi, Gen-Cheng Wu and Yan-Qing Wang
    Citation: Molecular Brain 2012 5:21
  31. Anxiety is a prevalent psychological disorder, in which the atypical expression of certain genes and the abnormality of amygdala are involved. Intermediate processes between genetic defects and anxiety, pathop...

    Authors: Fengyu Zhang, Bei Liu, Zhuofan Lei and Jin-Hui Wang
    Citation: Molecular Brain 2012 5:20
  32. Spinal glia, particularly microglia and astrocytes, are of the utmost importance in the development and maintenance of chronic pain. A recent study from our laboratory revealed that gabapentin, a recommended f...

    Authors: Jia-Le Yang, Bo Xu, Shuang-Shuang Li, Wei-Shi Zhang, Hua Xu, Xiao-Ming Deng and Yu-Qiu Zhang
    Citation: Molecular Brain 2012 5:18
  33. Huntington’s Disease (HD) is a devastating neurodegenerative disorder that clinically manifests as motor dysfunction, cognitive impairment and psychiatric symptoms. There is currently no cure for this progress...

    Authors: Tarja A Juopperi, Woon Ryoung Kim, Cheng-Hsuan Chiang, Huimei Yu, Russell L Margolis, Christopher A Ross, Guo-li Ming and Hongjun Song
    Citation: Molecular Brain 2012 5:17
  34. It has been reported that remarkable and sustained activation of astrocytes and/or microglia occurs in cancer induced pain (CIP), which is different from neuropathic and inflammatory pain. The present study wa...

    Authors: Qi-Liang Mao-Ying, Xiao-Wei Wang, Chang-Jiang Yang, Xiu Li, Wen-Li Mi, Gen-Cheng Wu and Yan-Qing Wang
    Citation: Molecular Brain 2012 5:16
  35. Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multip...

    Authors: Zheng Li and Morgan Sheng
    Citation: Molecular Brain 2012 5:15
  36. Over-activation of AMPARs (α−amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptors) is implicated in excitotoxic neuronal death associated with acute brain insults, such as ischemic st...

    Authors: Min Wang, Shupeng Li, Hongyu Zhang, Lin Pei, Shengwei Zou, Frank JS Lee, Yu Tian Wang and Fang Liu
    Citation: Molecular Brain 2012 5:13
  37. Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca2+ dysre...

    Authors: Jillian C Belrose, Yu-Feng Xie, Lynn J Gierszewski, John F MacDonald and Michael F Jackson
    Citation: Molecular Brain 2012 5:11

Affiliated with

Annual Journal Metrics

  • 2022 Citation Impact
    3.6 - 2-year Impact Factor
    4.6 - 5-year Impact Factor
    0.901 - SNIP (Source Normalized Impact per Paper)
    1.273 - SJR (SCImago Journal Rank)

    2022 Speed
    8 days submission to first editorial decision for all manuscripts (Median)
    69 days submission to accept (Median)

    2022 Usage 
    841,425 downloads
    8,166 Altmetric mentions 

Molecular Brain is a member of the Neuroscience Peer Review Consortium.

New Content Item (1)
Molecular Brain has partnered with Publons to give you official recognition for your contribution to peer review. Create a free profile to have your reviews automatically added.