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1. Development of selective blockers for Ca²⁺-activated Cl^- channel using Xenopus laevis oocytes with an improved drug screening strategy

   Ca²⁺-activated Cl^- channels (CaCCs) participate in many important physiological processes. However, the lack of effective and selective blockers has hindered the study of these channels, mostly due to the lack of...

   Authors: Soo-Jin Oh, Jung Hwan Park, Sungyu Han, Jae Kyun Lee, Eun Joo Roh and C Justin Lee

   Citation: Molecular Brain 2008 1:14

   Content type: Methodology Published on: 29 October 2008

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2. A role of p38 mitogen-activated protein kinase in adenosine A₁ receptor-mediated synaptic depotentiation in area CA1 of the rat hippocampus

   Although long-term potentiation (LTP) of synaptic strength is very persistent, current studies have provided evidence that various manipulations or pharmacological treatment when applied shortly after LTP indu...

   Authors: Ying-Ching Liang, Chiung-Chun Huang and Kuei-Sen Hsu

   Citation: Molecular Brain 2008 1:13

   Content type: Research Published on: 23 October 2008

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3. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease

   In previous work, we investigated dieldrin cytotoxicity and signaling cell death mechanisms in dopaminergic PC12 cells. Dieldrin has been reported to be one of the environmental factors correlated with Parkins...

   Authors: Anumantha G Kanthasamy, Masashi Kitazawa, Yongjie Yang, Vellareddy Anantharam and Arthi Kanthasamy

   Citation: Molecular Brain 2008 1:12

   Content type: Research Published on: 22 October 2008

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4. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

   Schizophrenia is a complex genetic disorder caused by multiple genetic and environmental factors. The dystrobrevin-binding protein 1 (DTNBP1: dysbindin-1) gene is a major susceptibility gene for schizophrenia....

   Authors: Keizo Takao, Keiko Toyama, Kazuo Nakanishi, Satoko Hattori, Hironori Takamura, Masatoshi Takeda, Tsuyoshi Miyakawa and Ryota Hashimoto

   Citation: Molecular Brain 2008 1:11

   Content type: Research Published on: 22 October 2008

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5. beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones

   Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), can associate with a common ...

   Authors: Eyleen LK Goh, Ju Kim Young, Kenichiro Kuwako, Marc Tessier-Lavigne, Zhigang He, John W Griffin and Guo-li Ming

   Citation: Molecular Brain 2008 1:10

   Content type: Research Published on: 15 October 2008

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6. Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats

   Long-term potentiation (LTP) in the hippocampal CA1 region requires the activation of N-methyl-D-aspartate receptors (NMDARs). Studies using genetic and pharmacological approaches have reported inconsistent re...

   Authors: Xue-Han Zhang, Long-Jun Wu, Bo Gong, Ming Ren, Bao-Ming Li and Min Zhuo

   Citation: Molecular Brain 2008 1:9

   Content type: Research Published on: 30 September 2008

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7. Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells

   The midbrain dopaminergic (mDA) neurons of the substantia nigra and the ventral tegmental area play a fundamental role in the control of voluntary movement and the regulation of emotion, and are severely affec...

   Authors: Emily Gale and Meng Li

   Citation: Molecular Brain 2008 1:8

   Content type: Review Published on: 30 September 2008

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8. Comprehensive behavioral phenotyping of calpastatin-knockout mice

   Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. Howev...

   Authors: Ryuichi Nakajima, Keizo Takao, Shu-Ming Huang, Jiro Takano, Nobuhisa Iwata, Tsuyoshi Miyakawa and Takaomi C Saido

   Citation: Molecular Brain 2008 1:7

   Content type: Research Published on: 15 September 2008

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9. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

   Elucidating the neural and genetic factors underlying psychiatric illness is hampered by current methods of clinical diagnosis. The identification and investigation of clinical endophenotypes may be one soluti...

   Authors: Nobuyuki Yamasaki, Motoko Maekawa, Katsunori Kobayashi, Yasushi Kajii, Jun Maeda, Miho Soma, Keizo Takao, Koichi Tanda, Koji Ohira, Keiko Toyama, Kouji Kanzaki, Kohji Fukunaga, Yusuke Sudo, Hiroshi Ichinose, Masashi Ikeda, Nakao Iwata…

   Citation: Molecular Brain 2008 1:6

   Content type: Research Published on: 10 September 2008

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10. Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?

    Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this clust...

    Authors: Paul W Frankland, Masanori Sakaguchi and Maithé Arruda-Carvalho

    Citation: Molecular Brain 2008 1:5

    Content type: Editorial Published on: 10 September 2008

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11. Atypical evening cortisol profile induces visual recognition memory deficit in healthy human subjects

    Diurnal rhythm-mediated endogenous cortisol levels in humans are characterised by a peak in secretion after awakening that declines throughout the day to an evening trough. However, a significant proportion of...

    Authors: Heather Gilpin, Daniel Whitcomb and Kwangwook Cho

    Citation: Molecular Brain 2008 1:4

    Content type: Research Published on: 21 August 2008

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12. Transcriptional regulation of long-term memory in the marine snail Aplysia

    Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new pr...

    Authors: Yong-Seok Lee, Craig H Bailey, Eric R Kandel and Bong-Kiun Kaang

    Citation: Molecular Brain 2008 1:3

    Content type: Review Published on: 17 June 2008

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13. Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance

    Morphine is widely used to treat chronic pain, however its utility is hindered by the development of tolerance to its analgesic effects. While N-methyl-D-aspartate (NMDA) receptors are known to play roles in m...

    Authors: Shanelle W Ko, Long-Jun Wu, Fanny Shum, Jessica Quan and Min Zhuo

    Citation: Molecular Brain 2008 1:2

    Content type: Research Published on: 17 June 2008

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14. Welcome to Molecular Brain

    We are delighted to announce the arrival of a brand new journal dedicated to the ever-expanding field of neuroscience. Molecular Brain is a peer-reviewed, open-access online journal that aims at publishing high q...

    Authors: Lin Mei, Kei Cho, C Justin Lee, Xiao-Jiang Li, Min Zhuo and Bong-Kiun Kaang

    Citation: Molecular Brain 2008 1:1

    Content type: Editorial Published on: 17 June 2008

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