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  1. Research

    Direct interaction with 14–3-3γ promotes surface expression of Best1 channel in astrocyte

    Bestrophin-1 (Best1) is a calcium-activated anion channel (CAAC) that is expressed broadly in mammalian tissues including the brain. We have previously reported that Best1 is expressed in hippocampal astrocyte...

    Soo-Jin Oh, Junsung Woo, Young-Sun Lee, Minhee Cho, Eunju Kim, Nam-Chul Cho, Jae-Yong Park, Ae Nim Pae, C. Justin Lee and Eun Mi Hwang

    Molecular Brain 2017 10:51

    Published on: 9 November 2017

  2. Research

    Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation

    Alterations in the strength of excitatory synapses in the hippocampus is believed to serve a vital function in the storage and recall of new information in the mammalian brain. These alterations involve the re...

    Fredrick E. Henry, William Hockeimer, Alex Chen, Shreesh P. Mysore and Michael A. Sutton

    Molecular Brain 2017 10:50

    Published on: 30 October 2017

  3. Research

    Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice

    Dopamine is important for motor control and involved in the regulation of circadian rhythm. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last i...

    Masayo Fujita, Yoko Hagino, Taishi Takeda, Shinya Kasai, Miho Tanaka, Yukio Takamatsu, Kazuto Kobayashi and Kazutaka Ikeda

    Molecular Brain 2017 10:49

    Published on: 16 October 2017

  4. Research

    Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis

    Chondroitin sulfate (CS) is an important glycosaminoglycan and is mainly found in the extracellular matrix as CS proteoglycans. In the brain, CS proteoglycans are highly concentrated in perineuronal nets (PNNs...

    Nozomu Yoshioka, Shinji Miyata, Atsushi Tamada, Yumi Watanabe, Asami Kawasaki, Hiroshi Kitagawa, Keizo Takao, Tsuyoshi Miyakawa, Kosei Takeuchi and Michihiro Igarashi

    Molecular Brain 2017 10:47

    Published on: 5 October 2017

  5. Research

    Novel miR-b2122 regulates several ALS-related RNA-binding proteins

    Common pathological features of amyotrophic lateral sclerosis (ALS) include cytoplasmic aggregation of several RNA-binding proteins. Out of these RNA-binding proteins, TDP-43, FUS/TLS and RGNEF have been shown...

    Zachary C. E. Hawley, Danae Campos-Melo and Michael J. Strong

    Molecular Brain 2017 10:46

    Published on: 2 October 2017

  6. Review

    HIV-associated synaptic degeneration

    Human immunodeficiency virus (HIV) infection induces neuronal injuries, with almost 50% of infected individuals developing HIV-associated neurocognitive disorders (HAND). Although highly activate antiretrovira...

    Wenjuan Ru and Shao-Jun Tang

    Molecular Brain 2017 10:40

    Published on: 29 August 2017

  7. Research

    Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

    We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient global ischemia, whereas receptor activat...

    Federica Mastroiacovo, Slavianka Moyanova, Milena Cannella, Anderson Gaglione, Remy Verhaeghe, Giovanna Bozza, Michele Madonna, Marta Motolese, Anna Traficante, Barbara Riozzi, Valeria Bruno, Giuseppe Battaglia, David Lodge and Ferdinando Nicoletti

    Molecular Brain 2017 10:39

    Published on: 18 August 2017

  8. Research

    An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias

    Lewy body dementias are the second most common cause of neurodegenerative dementia in the elderly after Alzheimer’s disease (AD). The two clinical subgroups of Lewy body dementias, namely, dementia with Lewy b...

    Arnab Datta, Yuek Ling Chai, Jing Min Tan, Jasinda H. Lee, Paul T. Francis, Christopher P. Chen, Siu Kwan Sze and Mitchell K. P. Lai

    Molecular Brain 2017 10:36

    Published on: 11 August 2017

  9. Research

    The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress

    The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulat...

    Qi-xin Shi, Liu-kun Yang, Wen-long Shi, Lu Wang, Shi-meng Zhou, Shao-yu Guan, Ming-gao Zhao and Qi Yang

    Molecular Brain 2017 10:38

    Published on: 11 August 2017

  10. Research

    A T-type channel-calmodulin complex triggers αCaMKII activation

    Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium cha...

    Hadhimulya Asmara, Ileana Micu, Arsalan P. Rizwan, Giriraj Sahu, Brett A. Simms, Fang-Xiong Zhang, Jordan D. T. Engbers, Peter K. Stys, Gerald W. Zamponi and Ray W. Turner

    Molecular Brain 2017 10:37

    Published on: 11 August 2017

  11. Review

    The role of melatonin in the onset and progression of type 3 diabetes

    Alzheimer’s disease (AD) is defined by the excessive accumulation of toxic peptides, such as beta amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFT). The risk factors associated with AD inclu...

    Juhyun Song, Daniel J. Whitcomb and Byeong C. Kim

    Molecular Brain 2017 10:35

    Published on: 1 August 2017

  12. Research

    O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease

    Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. O...

    Willayat Y. Wani, Xiaosen Ouyang, Gloria A. Benavides, Matthew Redmann, Stacey S. Cofield, John J. Shacka, John C. Chatham, Victor Darley-Usmar and Jianhua Zhang

    Molecular Brain 2017 10:32

    Published on: 19 July 2017

  13. Research

    SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model

    A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immed...

    Pascal Lösing, Cristina Elena Niturad, Merle Harrer, Christopher Meyer zu Reckendorf, Theresa Schatz, Daniela Sinske, Holger Lerche, Snezana Maljevic and Bernd Knöll

    Molecular Brain 2017 10:30

    Published on: 17 July 2017

  14. Research

    Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens

    Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to t...

    Eun Woo Kim, Benjamin U. Phillips, Christopher J. Heath, So Yeon Cho, Hyunjeong Kim, Jemeen Sreedharan, Ho-Taek Song, Jong Eun Lee, Timothy J. Bussey, Chul Hoon Kim, Eosu Kim and Lisa M. Saksida

    Molecular Brain 2017 10:31

    Published on: 17 July 2017

  15. Short report

    Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

    Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 ...

    Lei Chen, Tatiana Serdyuk, Beimeng Yang, Shuai Wang, Shiqing Chen, Xixia Chu, Xu Zhang, Jinjing Song, Hechen Bao, Chengbin Zhou, Xiang Wang, Shuangle Dong, Lulu Song, Fujun Chen, Guang He, Lin He…

    Molecular Brain 2017 10:29

    Published on: 3 July 2017

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