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  1. Research

    Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

    We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient global ischemia, whereas receptor activat...

    Federica Mastroiacovo, Slavianka Moyanova, Milena Cannella, Anderson Gaglione, Remy Verhaeghe, Giovanna Bozza, Michele Madonna, Marta Motolese, Anna Traficante, Barbara Riozzi, Valeria Bruno, Giuseppe Battaglia, David Lodge and Ferdinando Nicoletti

    Molecular Brain 2017 10:39

    Published on: 18 August 2017

  2. Research

    An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias

    Lewy body dementias are the second most common cause of neurodegenerative dementia in the elderly after Alzheimer’s disease (AD). The two clinical subgroups of Lewy body dementias, namely, dementia with Lewy b...

    Arnab Datta, Yuek Ling Chai, Jing Min Tan, Jasinda H. Lee, Paul T. Francis, Christopher P. Chen, Siu Kwan Sze and Mitchell K. P. Lai

    Molecular Brain 2017 10:36

    Published on: 11 August 2017

  3. Research

    The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress

    The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulat...

    Qi-xin Shi, Liu-kun Yang, Wen-long Shi, Lu Wang, Shi-meng Zhou, Shao-yu Guan, Ming-gao Zhao and Qi Yang

    Molecular Brain 2017 10:38

    Published on: 11 August 2017

  4. Research

    A T-type channel-calmodulin complex triggers αCaMKII activation

    Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium cha...

    Hadhimulya Asmara, Ileana Micu, Arsalan P. Rizwan, Giriraj Sahu, Brett A. Simms, Fang-Xiong Zhang, Jordan D. T. Engbers, Peter K. Stys, Gerald W. Zamponi and Ray W. Turner

    Molecular Brain 2017 10:37

    Published on: 11 August 2017

  5. Review

    The role of melatonin in the onset and progression of type 3 diabetes

    Alzheimer’s disease (AD) is defined by the excessive accumulation of toxic peptides, such as beta amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFT). The risk factors associated with AD inclu...

    Juhyun Song, Daniel J. Whitcomb and Byeong C. Kim

    Molecular Brain 2017 10:35

    Published on: 1 August 2017

  6. Research

    O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease

    Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. O...

    Willayat Y. Wani, Xiaosen Ouyang, Gloria A. Benavides, Matthew Redmann, Stacey S. Cofield, John J. Shacka, John C. Chatham, Victor Darley-Usmar and Jianhua Zhang

    Molecular Brain 2017 10:32

    Published on: 19 July 2017

  7. Research

    SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model

    A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immed...

    Pascal Lösing, Cristina Elena Niturad, Merle Harrer, Christopher Meyer zu Reckendorf, Theresa Schatz, Daniela Sinske, Holger Lerche, Snezana Maljevic and Bernd Knöll

    Molecular Brain 2017 10:30

    Published on: 17 July 2017

  8. Research

    Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens

    Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to t...

    Eun Woo Kim, Benjamin U. Phillips, Christopher J. Heath, So Yeon Cho, Hyunjeong Kim, Jemeen Sreedharan, Ho-Taek Song, Jong Eun Lee, Timothy J. Bussey, Chul Hoon Kim, Eosu Kim and Lisa M. Saksida

    Molecular Brain 2017 10:31

    Published on: 17 July 2017

  9. Short report

    Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

    Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 ...

    Lei Chen, Tatiana Serdyuk, Beimeng Yang, Shuai Wang, Shiqing Chen, Xixia Chu, Xu Zhang, Jinjing Song, Hechen Bao, Chengbin Zhou, Xiang Wang, Shuangle Dong, Lulu Song, Fujun Chen, Guang He, Lin He…

    Molecular Brain 2017 10:29

    Published on: 3 July 2017

  10. Short report

    Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage

    Toll-like receptor 2 (TLR2) was recently shown to contribute to secondary brain damage after intracerebral hemorrhage (ICH), although the molecular mechanisms of this contribution are elusive. In this study, w...

    Hyunjung Min, Boomin Choi, Yong Ho Jang, Ik-Hyun Cho and Sung Joong Lee

    Molecular Brain 2017 10:27

    Published on: 24 June 2017

  11. Review

    The role of 5-HT receptors in depression

    Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly...

    Christine N. Yohn, Mark M. Gergues and Benjamin Adam Samuels

    Molecular Brain 2017 10:28

    Published on: 24 June 2017

  12. Review

    Synaptoimmunology - roles in health and disease

    Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in norma...

    Robert Nisticò, Eric Salter, Celine Nicolas, Marco Feligioni, Dalila Mango, Zuner A. Bortolotto, Pierre Gressens, Graham L. Collingridge and Stephane Peineau

    Molecular Brain 2017 10:26

    Published on: 20 June 2017

  13. Research

    Ketamine-induced apoptosis in the mouse cerebral cortex follows similar characteristic of physiological apoptosis and can be regulated by neuronal activity

    The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs during this developmental window, it is ...

    Qi Wang, Feng-yan Shen, Rong Zou, Jing-jing Zheng, Xiang Yu and Ying-wei Wang

    Molecular Brain 2017 10:24

    Published on: 17 June 2017

  14. Research

    Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms

    Amyotrophic lateral sclerosis, a devastating neurodegenerative disease, is characterized by the progressive loss of motor neurons and the accumulation of misfolded protein aggregates. The latter suggests impai...

    Martin Madill, Katya McDonagh, Jun Ma, Alice Vajda, Paul McLoughlin, Timothy O’Brien, Orla Hardiman and Sanbing Shen

    Molecular Brain 2017 10:22

    Published on: 13 June 2017

  15. Research

    TREM2 protects against cerebral ischemia/reperfusion injury

    Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid ce...

    Rong Wu, Xiangpen Li, Pengfei Xu, Likui Huang, Jinping Cheng, Xiaolong Huang, Jingru Jiang, Long-Jun Wu and Yamei Tang

    Molecular Brain 2017 10:20

    Published on: 7 June 2017

  16. Research

    ApoE isoforms differentially regulates cleavage and secretion of BDNF

    Apolipoprotein E4 (ApoE4) is a major genetic risk factor for sporadic or late onset Alzheimer’s disease (AD). Brain-derived neurotrophic factor (BDNF) is decreased by 3 to 4-fold in the brains of AD patients a...

    Abhik Sen, Thomas J. Nelson and Daniel L. Alkon

    Molecular Brain 2017 10:19

    Published on: 1 June 2017

  17. Review

    Propagation of Tau aggregates

    Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagat...

    Michel Goedert and Maria Grazia Spillantini

    Molecular Brain 2017 10:18

    Published on: 30 May 2017

  18. Review

    Cortical kainate receptors and behavioral anxiety

    The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo ...

    Min Zhuo

    Molecular Brain 2017 10:16

    Published on: 18 May 2017

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