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  1. Brain metastasis is a common and lethal complication of non-small cell lung cancer (NSCLC). It is mostly diagnosed only after symptoms develop, at which point very few treatment options are available. Therefor...

    Authors: Yanjun Xu, Zhiyu Huang, Xiaoqing Yu, Kaiyan Chen and Yun Fan
    Citation: Molecular Brain 2021 14:176
    Content type: Research Published on:

  3. Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its m...

    Authors: Dae Hee Han, Ilgang Hong, Ja Eun Choi, Pojeong Park, Jun-Yeong Baek, HyoJin Park, Soichiro Ide, Masayoshi Mishina, Kazutaka Ikeda and Bong-Kiun Kaang
    Citation: Molecular Brain 2021 14:174
    Content type: Micro report Published on:

  4. Dopamine (DA) and norepinephrine (NE) are pivotal neuromodulators that regulate a broad range of brain functions, often in concert. Despite their physiological importance, untangling the relationship between D...

    Authors: Chihiro Nakamoto, Yuhei Goto, Yoko Tomizawa, Yuko Fukata, Masaki Fukata, Kasper Harpsøe, David E. Gloriam, Kazuhiro Aoki and Tomonori Takeuchi
    Citation: Molecular Brain 2021 14:173
    Content type: Methodology Published on:

  7. Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture ...

    Authors: Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda and Yu Hayashi
    Citation: Molecular Brain 2021 14:170
    Content type: Micro report Published on:

  8. Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables inve...

    Authors: Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker and Jeremy H. Herskowitz
    Citation: Molecular Brain 2021 14:169
    Content type: Research Published on:

  10. Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/...

    Authors: Andressa Radiske, Maria Carolina Gonzalez, Janine I. Rossato, Gênedy Apolinário, João R. de Oliveira, Lia R. M. Bevilaqua and Martín Cammarota
    Citation: Molecular Brain 2021 14:167
    Content type: Micro report Published on:

  11. T-type calcium channels are known molecular targets of certain phytocannabinoids and endocannabinoids. Here we explored the modulation of Cav3.2 T-type calcium channels by terpenes derived from cannabis plants...

    Authors: Vinicius M. Gadotti, Sun Huang and Gerald W. Zamponi
    Citation: Molecular Brain 2021 14:166
    Content type: Research Published on:

  12. REM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson’s disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid...

    Authors: Mikaeel Valli, Sang Soo Cho, Carme Uribe, Mario Masellis, Robert Chen, Alexander Mihaescu and Antonio P. Strafella
    Citation: Molecular Brain 2021 14:165
    Content type: Research Published on:

  13. Authors: Adan Hernandez, Chunfeng Tan, Florian Plattner, Aric F. Logsdon, Karine Pozo, Mohammad A. Yousuf, Tanvir Singh, Ryan C. Turner, Brandon P. Lucke-Wold, Jason D. Huber, Charles L. Rosen and James A. Bibb
    Citation: Molecular Brain 2021 14:164
    Content type: Correction Published on:

    The original article was published in Molecular Brain 2018 11:64

  14. We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns different from those of GFAP-expressing astrocytes (GFAP-astrocyte...

    Authors: Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori and Akio Wanaka
    Citation: Molecular Brain 2021 14:163
    Content type: Research Published on:

  15. Molecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic c...

    Authors: Nadine F. Joseph, Aya Zucca, Jenna L. Wingfield, Isabel Espadas, Damon Page and Sathyanarayanan V. Puthanveettil
    Citation: Molecular Brain 2021 14:162
    Content type: Research Published on:

  16. Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different ...

    Authors: Zhaoxiang Zhou, Penghai Ye, Xu-Hui Li, Yuxiang Zhang, Muhang Li, Qi-Yu Chen, Jing-Shan Lu, Man Xue, Yanan Li, Weiqi Liu, Lin Lu, Wantong Shi, Ping-Yi Xu and Min Zhuo
    Citation: Molecular Brain 2021 14:161
    Content type: Research Published on:

    The Correction to this article has been published in Molecular Brain 2022 15:58

  17. Songbirds are one of the few animal taxa that possess vocal learning abilities. Different species of songbirds exhibit species-specific learning programs during song acquisition. Songbirds with open-ended voca...

    Authors: Shin Hayase, Chengru Shao, Masahiko Kobayashi, Chihiro Mori, Wan-chun Liu and Kazuhiro Wada
    Citation: Molecular Brain 2021 14:160
    Content type: Research Published on:

  18. Neuroinflammation is an escalation factor shared by a vast range of central nervous system (CNS) pathologies, from neurodegenerative diseases to neuropsychiatric disorders. CNS immune status emerges by the int...

    Authors: Giulia Panattoni, Roberta Amoriello, Christian Memo, Agnes Thalhammer, Clara Ballerini and Laura Ballerini
    Citation: Molecular Brain 2021 14:159
    Content type: Research Published on:

  19. Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease. Modified composition of γ-secretase or mutations in its subunits h...

    Authors: Shekhar Kedia, Kousik Mandal, Pallavi Rao Netrakanti, Mini Jose, Sangram S. Sisodia and Deepak Nair
    Citation: Molecular Brain 2021 14:158
    Content type: Micro report Published on:

  20. Growth hormone secretagogue receptor 1a (GHS-R1a) is widely distributed in brain including the hippocampus. Studies have demonstrated the critical role of hippocampal ghrelin/GHS-R1a signaling in synaptic phys...

    Authors: Nan Li, Na Li, Fenghua Xu, Ming Yu, Zichen Qiao and Yu Zhou
    Citation: Molecular Brain 2021 14:157
    Content type: Micro report Published on:

  21. The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived fr...

    Authors: Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll and Cathryn L. Haigh
    Citation: Molecular Brain 2021 14:156
    Content type: Research Published on:

  22. Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic effects of t...

    Authors: Junmei Wang, Lydia Tierney, Ranjeet Mann, Thomas Lonsway and Chandler L. Walker
    Citation: Molecular Brain 2021 14:155
    Content type: Micro report Published on:

  23. The generation of mature synaptic structures using neurons differentiated from human-induced pluripotent stem cells (hiPSC-neurons) is expected to be applied to physiological studies of synapses in human cells...

    Authors: Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, Kousuke Baba, Hitoshi Hashimoto, Yuko Sekino, Tomoaki Shirao, Hideki Mochizuki and Yonehiro Kanemura
    Citation: Molecular Brain 2021 14:149
    Content type: Research Published on:

  24. Studies on the development of central nervous system (CNS) primarily rely on the use of specific molecular markers for different types of neural cells. S100B is widely being used as a specific marker for astro...

    Authors: Junqing Du, Min Yi, Fang Zhou, Wanjun He, Aifen Yang, Mengsheng Qiu and Hao Huang
    Citation: Molecular Brain 2021 14:154
    Content type: Research Published on:

  25. Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory...

    Authors: Yoonjeong Jeon, Yun Lim, Jiwoo Yeom and Eun-Kyoung Kim
    Citation: Molecular Brain 2021 14:153
    Content type: Research Published on:

  26. The glutamatergic signaling pathway is involved in molecular learning and human cognitive ability. Specific single variants (SNVs, formerly single-nucleotide polymorphisms) in the genes encoding N-methyl-d-aspart...

    Authors: Li-Ching Lee, Ming-Tsan Su, Hsing-Ying Huang, Ying-Chun Cho, Ting-Kuang Yeh and Chun-Yen Chang
    Citation: Molecular Brain 2021 14:152
    Content type: Research Published on:

  27. The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer and cardiovascular di...

    Authors: Aliza T. Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier and Brigitte L. Kieffer
    Citation: Molecular Brain 2021 14:151
    Content type: Research Published on:

  28. Post-traumatic stress disorder (PTSD) is a trauma-related disorder that is associated with pro-inflammatory activation and neurobiological impairments in the brain and leads to a series of affective-like behav...

    Authors: Yi-Hung Chen, Sheng-Yun Xie, Chao-Wei Chen and Dah-Yuu Lu
    Citation: Molecular Brain 2021 14:150
    Content type: Research Published on:

  29. The Cre/LoxP-based conditional knockout technology is a powerful tool for gene function analysis that allows region- and time-specific gene manipulation. However, inserting a pair of LoxP cassettes to generate...

    Authors: Hirofumi Nishizono, Yuki Hayano, Yoshihisa Nakahata, Yasuhito Ishigaki and Ryohei Yasuda
    Citation: Molecular Brain 2021 14:148
    Content type: Micro report Published on:

  30. Hypoxia typically accompanies acute inflammatory responses in patients and animal models. However, a limited number of studies have examined the effect of hypoxia in combination with inflammation (Hypo-Inf) on...

    Authors: Yoon-Sil Yang, Joon Ho Choi and Jong-Cheol Rah
    Citation: Molecular Brain 2021 14:147
    Content type: Research Published on:

  31. Chronic postsurgical pain (CPSP) is a serious problem. We developed a mouse model of CPSP induced by electrocautery and examined the mechanism of CPSP. In this mouse model, while both incision and electrocaute...

    Authors: Yosuke Katsuda, Kenichi Tanaka, Tomohisa Mori, Michiko Narita, Hideyuki Takeshima, Takashige Kondo, Yoshiyuki Yamabe, Misa Matsufuji, Daisuke Sato, Yusuke Hamada, Keisuke Yamaguchi, Toshikazu Ushijima, Eiichi Inada, Naoko Kuzumaki, Masako Iseki and Minoru Narita
    Citation: Molecular Brain 2021 14:146
    Content type: Research Published on:

  33. Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient variations in intracellular Ca2+. I...

    Authors: Yana Van Den Herrewegen, Thomas M. Sanderson, Surajit Sahu, Dimitri De Bundel, Zuner A. Bortolotto and Ilse Smolders
    Citation: Molecular Brain 2021 14:144
    Content type: Short report Published on:

  34. Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson’s disease. Here, we stud...

    Authors: Chelsie A. Kadgien, Anusha Kamesh and Austen J. Milnerwood
    Citation: Molecular Brain 2021 14:143
    Content type: Research Published on:

  35. Assessment of neural activity in the specific brain area is critical for understanding the circuit mechanisms underlying altered brain function and behaviors. A number of immediate early genes (IEGs) that are ...

    Authors: Sang Ho Yoon, Woo Seok Song, Sung Pyo Oh, Young Sook Kim and Myoung-Hwan Kim
    Citation: Molecular Brain 2021 14:142
    Content type: Micro report Published on:

  36. Arginine vasopressin (AVP) is expressed in both hypothalamic and extra-hypothalamic neurons. The expression and role of AVP exhibit remarkable divergence between these two neuronal populations. Polysynaptic pa...

    Authors: Wen Han Tong, Samira Abdulai-Saiku and Ajai Vyas
    Citation: Molecular Brain 2021 14:141
    Content type: Micro report Published on:

  37. Previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) is one of the diffusible messengers for enhancing synaptic transmission in the hippocampus. Less information is available about ...

    Authors: Hui-Hui Miao, Zhuang Miao, Ji-Gang Pan, Xu-Hui Li and Min Zhuo
    Citation: Molecular Brain 2021 14:140
    Content type: Research Published on:

  38. Chronic pain easily leads to concomitant mood disorders, and the excitability of anterior cingulate cortex (ACC) pyramidal neurons (PNs) is involved in chronic pain-related anxiety. However, the mechanism by w...

    Authors: Fang-bing Shao, Jun-fan Fang, Si-si Wang, Meng-ting Qiu, Dan-ning Xi, Xiao-ming Jin, Jing-gen Liu, Xiao-mei Shao, Zui Shen, Yi Liang, Jian-qiao Fang and Jun-ying Du
    Citation: Molecular Brain 2021 14:139
    Content type: Research Published on:

  39. To understand the information encoded in a connection between the neurons, postsynaptic current (PSC) has been widely measured as a primary index of synaptic strength in the field of neurophysiology. Although ...

    Authors: Yong Gyu Kim, Jae Jin Shin and Sang Jeong Kim
    Citation: Molecular Brain 2021 14:138
    Content type: Methodology Published on:

  40. We recently showed that synaptophysin (Syph) and synapsin (Syn) can induce liquid–liquid phase separation (LLPS) to cluster small synaptic-like microvesicles in living cells which are highly reminiscent of SV ...

    Authors: Goeun Kim, Sang-Eun Lee, Seonyoung Jeong, Jeongkun Lee, Daehun Park and Sunghoe Chang
    Citation: Molecular Brain 2021 14:137
    Content type: Short report Published on:

  42. Experimental animals, such as non-human primates (NHPs), mice, Zebrafish, and Drosophila, are frequently employed as models to gain insights into human physiology and pathology. In developmental neuroscience a...

    Authors: Ryuichi Nakajima, Hideo Hagihara and Tsuyoshi Miyakawa
    Citation: Molecular Brain 2021 14:135
    Content type: Micro report Published on:

  44. Cumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, the role of interaction between gut dysbiosis and C-reactive protein (CRP) in th...

    Authors: Yujing Chen, Peilin Meng, Shiqiang Cheng, Yumeng Jia, Yan Wen, Xuena Yang, Yao Yao, Chuyu Pan, Chun’e Li, Huijie Zhang, Jingxi Zhang, Zhen Zhang and Feng Zhang
    Citation: Molecular Brain 2021 14:133
    Content type: Research Published on:

  45. The medium-chain fatty acids octanoic acid (C8) and decanoic acid (C10) are gaining attention as beneficial brain fuels in several neurological disorders. The protective effects of C8 and C10 have been propose...

    Authors: Jens V. Andersen, Emil W. Westi, Emil Jakobsen, Nerea Urruticoechea, Karin Borges and Blanca I. Aldana
    Citation: Molecular Brain 2021 14:132
    Content type: Research Published on:

  47. Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs), and, in turn, provide feedback inhibition onto...

    Authors: Anne-Sophie Racine, François-Xavier Michon, Isabel Laplante and Jean-Claude Lacaille
    Citation: Molecular Brain 2021 14:130
    Content type: Research Published on:

  48. Hypobaric hypoxia (HH) is a typical characteristic of high altitude environment and causes a spectrum of pathophysiological effects, including headaches, gliovascular dysfunction and cognitive retardation. Her...

    Authors: Yang Zhou, Huanyu Lu, Ying Liu, Zaihua Zhao, Qian Zhang, Chong Xue, Yuankang Zou, Zipeng Cao and Wenjing Luo
    Citation: Molecular Brain 2021 14:129
    Content type: Research Published on:

  49. Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement. Here we tested whether treatment with the histo...

    Authors: Maxinne Watchon, Luan Luu, Katherine J. Robinson, Kristy C. Yuan, Alana De Luca, Hannah J. Suddull, Madelaine C. Tym, Gilles J. Guillemin, Nicholas J. Cole, Garth A. Nicholson, Roger S. Chung, Albert Lee and Angela S. Laird
    Citation: Molecular Brain 2021 14:128
    Content type: Research Published on:
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