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  1. Psychiatric disorders are affected by genetic susceptibility and environmental adversities. Therefore, the regulation of gene expression under certain environments, such as stress, is a key issue in psychiatri...

    Authors: Jungyoung Park, Joonhee Lee, Koeul Choi and Hyo Jung Kang

    Citation: Molecular Brain 2021 14:7

    Content type: Micro report

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  2. As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. Howe...

    Authors: So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo and Dong-Hyung Cho

    Citation: Molecular Brain 2021 14:6

    Content type: Micro report

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  3. Reduced expression of glutamate decarboxylase 67 (GAD67), encoded by the Gad1 gene, is a consistent finding in postmortem brains of patients with several psychiatric disorders, including schizophrenia, bipolar di...

    Authors: Shigeo Miyata, Toshikazu Kakizaki, Kazuyuki Fujihara, Hideru Obinata, Touko Hirano, Junichi Nakai, Mika Tanaka, Shigeyoshi Itohara, Masahiko Watanabe, Kenji F. Tanaka, Manabu Abe, Kenji Sakimura and Yuchio Yanagawa

    Citation: Molecular Brain 2021 14:5

    Content type: Research

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  4. A novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia. This mutation leads to a s...

    Authors: Eder Gambeta, Maria A. Gandini, Ivana A. Souza, Laurent Ferron and Gerald W. Zamponi

    Citation: Molecular Brain 2021 14:4

    Content type: Short report

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  5. To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.

    Authors: Xiao Liang, ShiQiang Cheng, Jing Ye, XiaoMeng Chu, Yan Wen, Li Liu, Xin Qi, YuMeng Jia and Feng Zhang

    Citation: Molecular Brain 2021 14:3

    Content type: Research

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  6. Formation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs ...

    Authors: Min Soo Kang and Jin-Hee Han

    Citation: Molecular Brain 2021 14:2

    Content type: Micro report

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  7. CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional...

    Authors: Dong Il Choi, Myeongwon Kim, Somi Kim, Nam-Kyung Yu, Chuljung Kwak, Hyunhyo Seo, Kyungmin Lee and Bong-Kiun Kaang

    Citation: Molecular Brain 2021 14:1

    Content type: Micro report

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  8. Corticogenesis is one of the most critical and complicated processes during embryonic brain development. Any slight impairment in corticogenesis could cause neurodevelopmental disorders such as Fragile X syndr...

    Authors: Cristine R. Casingal, Takako Kikkawa, Hitoshi Inada, Yukio Sasaki and Noriko Osumi

    Citation: Molecular Brain 2020 13:167

    Content type: Research

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  9. Disturbances of attention are a common behavioral feature associated with neuropsychiatric disorders with largely unknown underlying causes. We previously developed an object-based attention test (OBAT) as a s...

    Authors: Bolati Wulaer, Kazuo Kunisawa, Hisayoshi Kubota, Willy Jaya Suento, Kuniaki Saito, Akihiro Mouri and Toshitaka Nabeshima

    Citation: Molecular Brain 2020 13:171

    Content type: Micro report

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  10. Immune molecules, such as cytokines, complement, and major histocompatibility complex (MHC) proteins, in the central nervous system are often associated with neuropsychiatric disorders. Neuronal MHC class I (M...

    Authors: Bolati Wulaer, Kazuhiro Hada, Akira Sobue, Norimichi Itoh, Toshitaka Nabeshima, Taku Nagai and Kiyofumi Yamada

    Citation: Molecular Brain 2020 13:170

    Content type: Research

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  11. The brain is composed of cells having distinct genomic DNA sequences that arise post-zygotically, known as somatic genomic mosaicism (SGM). One form of SGM is aneuploidy—the gain and/or loss of chromosomes—whi...

    Authors: Whitney S. McDonald, Kyoko Miyamoto, Richard Rivera, Grace Kennedy, Beatriz S. V. Almeida, Marcy A. Kingsbury and Jerold Chun

    Citation: Molecular Brain 2020 13:169

    Content type: Research

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  12. Dysfunctional dendritic arborization is a key feature of many developmental neurological disorders. Across various human brain regions, basal dendritic complexity is known to increase along a caudal-to-rostral...

    Authors: Brian D. Swinehart, Katherine M. Bland, Z. Logan Holley, Andrew J. Lopuch, Zachary O. Casey, Christopher J. Handwerk and George S. Vidal

    Citation: Molecular Brain 2020 13:168

    Content type: Short report

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  13. The low-density lipoprotein receptor-related protein 4 (LRP4) is essential for inducing the neuromuscular junction (NMJ) formation in muscle fibers, and LRP4 plays a critical role in dendritic development and ...

    Authors: Min Yan, Amin Guo, Peng Chen, Hongyang Jing, Dongyan Ren, Yanzi Zhong, Yongqiang Wu, Erkang Fei, Xinsheng Lai, Suqi Zou and Shunqi Wang

    Citation: Molecular Brain 2020 13:166

    Content type: Research

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  14. Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in t...

    Authors: Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan and Li Zeng

    Citation: Molecular Brain 2020 13:164

    Content type: Research

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  15. Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel CaV3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountere...

    Authors: Naoyuki Hara, Hiroyuki Morino, Yukiko Matsuda, Kenichi Satoh, Kouichi Hashimoto, Hirofumi Maruyama and Hideshi Kawakami

    Citation: Molecular Brain 2020 13:163

    Content type: Research

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  16. Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor o...

    Authors: Zhuxi Liu, Caiqin Li, Xuelian Fan, Yifang Kuang, Xu Zhang, Lei Chen, Jinjing Song, Ying Zhou, Eiki Takahashi, Guang He and Weidong Li

    Citation: Molecular Brain 2020 13:162

    Content type: Short report

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  17. Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we further explore the presynaptic role of CCL2. Behavioral experimen...

    Authors: Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo and Rou-Gang Xie

    Citation: Molecular Brain 2020 13:161

    Content type: Research

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  18. CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 muta...

    Authors: Atsuki Kawamura, Yoshifumi Abe, Fumiko Seki, Yuta Katayama, Masaaki Nishiyama, Norio Takata, Kenji F. Tanaka, Hideyuki Okano and Keiichi I. Nakayama

    Citation: Molecular Brain 2020 13:160

    Content type: Research

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  19. Paranodal axoglial junctions are essential for rapid nerve conduction and the organization of axonal domains in myelinated axons. Neurofascin155 (Nfasc155) is a glial cell adhesion molecule that is also requir...

    Authors: Kazuo Kunisawa, Nobuhiko Hatanaka, Takeshi Shimizu, Kenta Kobayashi, Yasuyuki Osanai, Akihiro Mouri, Qian Shi, Manzoor A. Bhat, Atsushi Nambu and Kazuhiro Ikenaka

    Citation: Molecular Brain 2020 13:159

    Content type: Short report

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  20. Neuropathic pain induced by a nerve injury can lead to chronic pain. Recent studies have reported hyperactive neural activities in the nociceptive-related area of the brain as a result of chronic pain. Althoug...

    Authors: Myeounghoon Cha, Songyeon Choi, Kyeongmin Kim and Bae Hwan Lee

    Citation: Molecular Brain 2020 13:158

    Content type: Research

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  21. We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a fu...

    Authors: Won-Mo Jung, Ye-Seul Lee, In-Seon Lee, Christian Wallraven, Yeonhee Ryu and Younbyoung Chae

    Citation: Molecular Brain 2020 13:157

    Content type: Research

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  22. Long-term memory formation is supported by functional and structural changes of neuronal networks, which rely on de novo gene transcription and protein synthesis. The modulation of the neuronal transcriptome i...

    Authors: David V. C. Brito, Kubra Gulmez Karaca, Janina Kupke, Lukas Frank and Ana M. M. Oliveira

    Citation: Molecular Brain 2020 13:156

    Content type: Research

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  23. Olig2 transcription factor is essential for the maintenance of neural progenitor cells (NPCs) in the pMN domain and their sequential specification into motor neurons (MNs) and oligodendrocyte precursor cells (OPC...

    Authors: Min Jiang, Dan Yu, Binghua Xie, Hao Huang, Wenwen Lu, Mengsheng Qiu and Zhong-Min Dai

    Citation: Molecular Brain 2020 13:155

    Content type: Micro report

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  24. Long interspersed element-1 (LINE-1/L1) is the only autonomous transposable element in the human genome that currently mobilises in both germline and somatic tissues. Recent studies have identified correlation...

    Authors: Abigail L. Savage, Ana Illera Lopez, Alfredo Iacoangeli, Vivien J. Bubb, Bradley Smith, Claire Troakes, Nada Alahmady, Sulev Koks, Gerald G. Schumann, Ammar Al-Chalabi and John P. Quinn

    Citation: Molecular Brain 2020 13:154

    Content type: Research

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  25. Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl2 is not only a hypoxia-mimetic reagent but also an...

    Authors: Han-Byeol Kim, Ji-Young Yoo, Seung-Yeon Yoo, Jun-Ho Lee, Wonseok Chang, Hye-Sun Kim, Tai-Kyoung Baik and Ran-Sook Woo

    Citation: Molecular Brain 2020 13:153

    Content type: Research

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  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kohei Koga, Akihiro Yamada, Qian Song, Xu-Hui Li, Qi-Yu Chen, Ren-Hao Liu, Jun Ge, Cheng Zhan, Hidemasa Furue, Min Zhuo and Tao Chen

    Citation: Molecular Brain 2020 13:152

    Content type: Correction

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    The original article was published in Molecular Brain 2020 13:49

  27. Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline with accumulation of amyloid beta (Aβ) and neurofibrillary tangles that usually begins 15–30 years before...

    Authors: Md. Ali Bin Saifullah, Okiru Komine, Yutao Dong, Kazuya Fukumoto, Akira Sobue, Fumito Endo, Takashi Saito, Takaomi C. Saido, Koji Yamanaka and Hiroyuki Mizoguchi

    Citation: Molecular Brain 2020 13:147

    Content type: Research

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  28. The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and fu...

    Authors: Camille Dumon, Yasmine Belaidouni, Diabe Diabira, Suzanne M. Appleyard, Gary A. Wayman and Jean-Luc Gaiarsa

    Citation: Molecular Brain 2020 13:151

    Content type: Short report

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  29. The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Ba...

    Authors: Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos and Javier Garzón-Niño

    Citation: Molecular Brain 2020 13:150

    Content type: Research

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  30. Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel a...

    Authors: Vendula Ficelova, Ivana A. Souza, Leos Cmarko, Maria A. Gandini, Robin N. Stringer, Gerald W. Zamponi and Norbert Weiss

    Citation: Molecular Brain 2020 13:149

    Content type: Micro report

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  31. Neuronal activity-regulated gene transcription underlies plasticity-dependent changes in the molecular composition and structure of neurons. A large number of genes regulated by different neuronal plasticity i...

    Authors: Johanna Denkena, Andrea Zaisser, Barbara Merz, Bertram Klinger, Dietmar Kuhl, Nils Blüthgen and Guido Hermey

    Citation: Molecular Brain 2020 13:148

    Content type: Research

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  32. Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give r...

    Authors: Michiko Shirane, Hirotaka Shoji, Yutaka Hashimoto, Hiroyuki Katagiri, Shizuka Kobayashi, Toshiya Manabe, Tsuyoshi Miyakawa and Keiichi I. Nakayama

    Citation: Molecular Brain 2020 13:146

    Content type: Research

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  33. Activity-dependent local protein synthesis is critical for synapse-specific, persistent plasticity. Abnormalities in local protein synthesis have been implicated in psychiatric disorders. We have recently iden...

    Authors: Alan Jung Park, Mahesh Shivarama Shetty, Jay M. Baraban and Ted Abel

    Citation: Molecular Brain 2020 13:145

    Content type: Research

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    The Correction to this article has been published in Molecular Brain 2021 14:48

  34. Itch is defined as an unpleasant sensation that provokes a desire to scratch. Our understanding of neuronal circuits for itch information transmission and processing in the spinal dorsal horn (SDH) has progres...

    Authors: Keisuke Koga, Yuto Shiraishi, Ryo Yamagata, Hidetoshi Tozaki-Saitoh, Miho Shiratori-Hayashi and Makoto Tsuda

    Citation: Molecular Brain 2020 13:144

    Content type: Research

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  35. Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stres...

    Authors: Madhuvika Murugan, Jiaying Zheng, Gongxiong Wu, Rochelle Mogilevsky, Xin Zheng, Peiwen Hu, Junfang Wu and Long-Jun Wu

    Citation: Molecular Brain 2020 13:143

    Content type: Research

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  36. To prevent or delay the onset of Alzheimer’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rar...

    Authors: Karissa Barthelson, Stephen Martin Pederson, Morgan Newman and Michael Lardelli

    Citation: Molecular Brain 2020 13:142

    Content type: Research

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  37. α2-Antiplasmin (α2AP), a principal physiological plasmin inhibitor, is mainly produced by the liver and kidneys, but it is also expressed in several parts of the brain, including the hippocampus and cerebral c...

    Authors: Eri Kawashita, Keiichi Ishihara, Haruko Miyaji, Yu Tanishima, Akiko Kiriyama, Osamu Matsuo and Satoshi Akiba

    Citation: Molecular Brain 2020 13:140

    Content type: Research

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  38. The comorbidities of depression and chronic pain have long been recognized in the clinic, and several preclinical studies have demonstrated depression-like behaviors in animal models of chronic pain. These fin...

    Authors: Ryuto Hara, Daiki Takahashi, Tatsuhiro Takehara, Taiju Amano and Masabumi Minami

    Citation: Molecular Brain 2020 13:139

    Content type: Micro report

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  39. Recombinant adeno-associated viruses (rAAVs), particularly those that permit efficient gene transfer to neurons from axonal terminals or across the blood–brain barrier, are useful vehicles for structural and f...

    Authors: Kunzhang Lin, Xin Zhong, Lei Li, Min Ying, Tian Yang, Zhijian Zhang, Xiaobin He and Fuqiang Xu

    Citation: Molecular Brain 2020 13:138

    Content type: Methodology

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  40. Mutations in the Vacuolar protein sorting 35 (VPS35) gene have been linked to familial Parkinson’s disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal t...

    Authors: Keiko Bono, Chikako Hara-Miyauchi, Shunsuke Sumi, Hisayoshi Oka, Yasuyuki Iguchi and Hirotaka James Okano

    Citation: Molecular Brain 2020 13:137

    Content type: Research

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  41. Cerebral microinfarcts (MIs) lead to progressive cognitive impairments in the elderly, and there is currently no effective preventative strategy due to uncertainty about the underlying pathogenic mechanisms. O...

    Authors: Xiao-fei He, Ge Li, Li-li Li, Ming-yue Li, Feng-yin Liang, Xi Chen and Xi-quan Hu

    Citation: Molecular Brain 2020 13:135

    Content type: Research

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  42. Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Althoug...

    Authors: Min-Jae Jeong, Changhee Lee, Kibong Sung, Jung Hoon Jung, Jung Hyun Pyo and Joung-Hun Kim

    Citation: Molecular Brain 2020 13:134

    Content type: Research

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  43. Increased neural activities reduced pH at the synaptic cleft and interstitial spaces. Recent studies have shown that protons function as a neurotransmitter. However, it remains unclear whether protons signal t...

    Authors: Yuanyuan Xu, Mike T. Lin and Xiang-ming Zha

    Citation: Molecular Brain 2020 13:132

    Content type: Micro report

    Published on:

    The Correction to this article has been published in Molecular Brain 2021 14:40

  44. Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disease characterized by Aβ accumulation and tau hyperphosphorylation. Epidemiological evidence for a negative correlation between cancer and AD...

    Authors: Seong Gak Jeon, Hyun-ju Lee, HyunHee Park, Kyung-Min Han and Hyang-Sook Hoe

    Citation: Molecular Brain 2020 13:131

    Content type: Micro report

    Published on:

  45. The goal of the present study was to elucidate the mechanism by which long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) promotes inflammation in Parkinson’s disease (PD...

    Authors: Li-Jun Cai, Li Tu, Xiao-Mo Huang, Jia Huang, Nan Qiu, Guang-Hong Xie, Jian-Xiong Liao, Wei Du, Ying-Yue Zhang and Jin-Yong Tian

    Citation: Molecular Brain 2020 13:130

    Content type: Research

    Published on:

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